Dimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burns

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dc.contributor.authorAltan, Semih
dc.contributor.authorOgurtan, Zeki
dc.date.accessioned2020-03-26T19:34:53Z
dc.date.available2020-03-26T19:34:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: In this study, we aimed to investigate the effect of indomethacin and dimethyl sulfoxide (DMSO), well-known antioxidant and anti-inflammatory agents, to heal eye burns induced with hydrofluoric acid in rabbits. Methods: After general anesthesia, the right eye of 72 male New Zealand rabbits were burned by instillation of 2% hydrofluoric acid for 60 s. Following this, the eyes were irrigated with 500 cc normal saline. The rabbits were then divided into four groups of 18 rabbits each. Group D was instilled dimethyl sulfoxide 40%, Group I indomethacin 0.1%, and Group DI dimethyl sulfoxide together with indomethacin for 2, 7, and 14 treatment days, respectively. Group C received no instilled drug as control. Treatment efficacies were evaluated as clinical (corneal haziness, conjunctival status, conjunctivitis, corneal erosion area, and intraocular pressure) and histopathological (inflammatory cell infiltration, vascularization, stromal thickness, reepithelization, proliferating cell nuclear antigen [PCNA], apoptosis, and inducible nitric oxide synthases [iNOS]). Results: In terms of corneal haziness and erosion area at days 7 and 14, group D showed the best result statistically as compared to the other groups. This group also showed the best result statistically for reepithelization rate, stromal thickness, and inflammatory cell end at day 14 as compared to the other groups. Conclusions: Dimethyl sulfoxide (40%) was efficient to induce reepithelization on mild hydrofluoric acid eye burns, whereas 0.1% indomethacin both alone and along with DMSO poorly induced reepithelization and exacerbated inflammation. Thus, 40% DMSO could be used for the treatment of corneal disorders. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects (BAP) coordinating officeSelcuk University [10102019]en_US
dc.description.sponsorshipWe would like to thank Prof. Dr. Ilhami Celik, Assoc. Prof. Dr. Yasemin Oznurlu, and Assoc. Prof. Dr. Tugba Ozaydin for their support regarding preparation of histopathological sections. This study is a part of the PhD Thesis of Dr. Semih Altan, funded by Selcuk University Scientific Research Projects (BAP) coordinating office, with the project number 10102019.en_US
dc.identifier.doi10.1016/j.burns.2016.09.026en_US
dc.identifier.endpage244en_US
dc.identifier.issn0305-4179en_US
dc.identifier.issn1879-1409en_US
dc.identifier.issue1en_US
dc.identifier.pmid28341026en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.burns.2016.09.026
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34970
dc.identifier.volume43en_US
dc.identifier.wosWOS:000392476000033en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofBURNSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDimethylsulfoxideen_US
dc.subjectEyeen_US
dc.subjectBurnen_US
dc.subjectIndomethacinen_US
dc.subjectHydrofluoric aciden_US
dc.titleDimethyl sulfoxide but not indomethacin is efficient for healing in hydrofluoric acid eye burnsen_US
dc.typeArticleen_US

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