The Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorKayikcioglu, Hatice
dc.contributor.authorOzbek, Orhan
dc.contributor.authorSolak, Yalcin
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorSamur, Cigdem
dc.contributor.authorAnil, Melih
dc.date.accessioned2020-03-26T18:17:10Z
dc.date.available2020-03-26T18:17:10Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objectives Malnutrition, inflammation, atherosclerosis/calcification (MIAC) and endothelial dysfunction are the most commonly encountered risk factors in the pathogenesis of cardiovascular disease in ESRD patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between CAD and EAT was shown in patients with high risk of coronary artery disease. In this study, we aimed to investigate the relationship between EAT and MIAC syndrome in ESRD patients. Design, setting, participants, & measurements Eighty ESRD patients and 27 healthy subjects enrolled in this cross-sectional study. EAT and coronary artery calcification score were measured by a multidetector computed tomography (MDCT) scanner. Patients with serum albumin <3.5 mg/dl were defined as patients with malnutrition; those with serum C-reactive protein level >10 ng/dl (normal range, 0-5 ng/dl) had inflammation; and those with CACS >10 had atheroscleosis/calcification. Results Total CACS and EAT measurements were significantly higher in ESRD patients when compared with healthy subjects. There was a statistically significant relationship between EAT and CACS in ESRD patients (r = 0.48). EAT measurements were higher in PD patients than HD patients. Twenty-four of the patients had no component, 31 had one component, 17 had two components, and nine had all of the MIAC components. EAT was found to be significantly increased when the presence of MIAC components increased. EAT was positively correlated with age, body mass index, and presence of MIAC. These parameters were also found as independent predictors of increased EAT. Conclusions We found a relationship between EAT and components of MTAC syndrome in ESRD patients. J Am Soc Nephrol 6: 1920-1925, 2011. doi: 10.2215/CJN.00890111en_US
dc.description.sponsorshipScientific Investigation and Project Foundation of Selcuk University Meram School of MedicineSelcuk Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Investigation and Project Foundation of Selcuk University Meram School of Medicine.en_US
dc.identifier.doi10.2215/CJN.00890111en_US
dc.identifier.endpage1925en_US
dc.identifier.issn1555-9041en_US
dc.identifier.issn1555-905Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid21757644en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1920en_US
dc.identifier.urihttps://dx.doi.org/10.2215/CJN.00890111
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26988
dc.identifier.volume6en_US
dc.identifier.wosWOS:000293721400019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER SOC NEPHROLOGYen_US
dc.relation.ispartofCLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Relationship between Epicardial Adipose Tissue and Malnutrition, Inflammation, Atherosclerosis/Calcification Syndrome in ESRD Patientsen_US
dc.typeArticleen_US

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