Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts

Basit Öğe Kaydı
dc.contributor.authorMocan, Andrei
dc.contributor.authorZengin, Gökhan
dc.contributor.authorCrisan, Gianina
dc.contributor.authorMollica, Adriano
dc.date.accessioned2020-03-26T19:23:59Z
dc.date.available2020-03-26T19:23:59Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractConsiderable interest has been shown in natural sources and their compounds in developing new therapeutically agents for different diseases. In this framework, investigations performed on this topic play a central role for human health and drug development process. Schisandra chinensis (Turcz.) Baill is a medicinal and edible plant showing highly advantageous bioactivity and nutritional value. The main bioactive compounds from its fruits are lignans, derivatives of dibenzocyclooctadiene whereas concerning its leaves, phenolic acids, and flavonoids are dominant. The purpose of this study was to investigate the enzyme inhibitory potential on selected carbohydrate hydrolases, cholinesterases, and tyrosinase of extracts from fruits and leaves of Schisandra in relation with their main bioactive compounds. Furthermore, the interactions between dominant compounds (schisandrol A, schisandrol B, schisandrin B, and cinnamic acid) from extracts and selected enzymes were investigated by molecular modeling and molecular dynamic studies in order to explain at a molecular level our findings.en_US
dc.identifier.doi10.1080/14756366.2016.1222585en_US
dc.identifier.endpage210en_US
dc.identifier.issn1475-6366en_US
dc.identifier.issn1475-6374en_US
dc.identifier.pmid27595863en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14756366.2016.1222585
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33549
dc.identifier.volume31en_US
dc.identifier.wosWOS:000391904900025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectmolecular modelingen_US
dc.subjectlignansen_US
dc.subjectphenolicsen_US
dc.subjectSchisandra chinensisen_US
dc.titleEnzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extractsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu