Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy

dc.contributor.authorArhan, Ebru
dc.contributor.authorSerdaroglu, Ayse
dc.contributor.authorOzturk, Bahadir
dc.contributor.authorOzturk, H. Serdar
dc.contributor.authorOzcelik, Aysima
dc.contributor.authorKurt, Nese
dc.contributor.authorKutsal, Ebru
dc.date.accessioned2020-03-26T18:14:22Z
dc.date.available2020-03-26T18:14:22Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the effects of epilepsy, valproic acid and oxcarbazepine on nitric oxide levels, lipid peroxidation and xanthine oxidase levels in newly diagnosed epileptic children and healthy controls. A total of 49 patients with newly diagnosed idiopathic epilepsy and 15 healthy children were enrolled in this study. Of these 49 patients, 16 children were treated with valproate and 16 treated with oxcarbazepine. Nitric oxide, malondialdehyde and xanthine oxidase levels prior to antiepileptic drug therapy were measured in the serum. Blood samples were drawn before antiepileptic drug therapy and after 3 and 6 months of the antiepileptic drug treatment. Nitric oxide levels were statistically higher in the newly diagnosed epileptic patients. In oxcarbazepine group, the nitric oxide and malondialdehyde levels were found to be decreased. No statistically significant differences were noted in nitric oxide, malondialdehyde and xanthine oxidase levels in valproic acid treated group. Oxcarbazepine which is a frequently used new antiepileptic drug in childhood epilepsy may modify nitric oxide levels and lipid peroxidation. These results suggest that decreased lipid peroxidation would play a role in the mechanism of antiepileptic effects by oxcarbazepine treatment. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.seizure.2010.11.003en_US
dc.identifier.endpage142en_US
dc.identifier.issn1059-1311en_US
dc.identifier.issn1532-2688en_US
dc.identifier.issue2en_US
dc.identifier.pmid21112224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.seizure.2010.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26404
dc.identifier.volume20en_US
dc.identifier.wosWOS:000288294900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO LTDen_US
dc.relation.ispartofSEIZURE-EUROPEAN JOURNAL OF EPILEPSYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIdiopathic childhood epilepsyen_US
dc.subjectNitric oxideen_US
dc.subjectLipid peroxidationen_US
dc.subjectXanthine oxidaseen_US
dc.subjectValproic aciden_US
dc.subjectOxcarbazepineen_US
dc.titleEffects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsyen_US
dc.typeArticleen_US

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