Portal and splenic hemodynamics in cirrhotic patients: relationship between esophageal variceal bleeding and the severity of hepatic failure

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dc.contributor.authorKayacetin, E
dc.contributor.authorEfe, D
dc.contributor.authorDogan, C
dc.date.accessioned2020-03-26T16:55:25Z
dc.date.available2020-03-26T16:55:25Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground The relationship between portal and splenic vein hemodynamics, liver function, and esophageal variceal bleeding in patients with cirrhosis remains unclear. The aim of the present study was to investigate quantitative Doppler parameters of splanchnic hemodynamics in cirrhotic patients and to determine the value of the Doppler parameters in predicting esophageal variceal bleeding. Methods. With the help of pulsed Doppler ultrasonography, we investigated portal and splenic hemodynamics in 18 healthy controls and in 45 patients with liver cirrhosis, in whom the relationship of splenic hemodynamics with esophageal variceal bleeding and the grade of cirrhosis was examined. Results. Portal flow velocity was decreased in cirrhotic patients with Child's C cirrhosis, as compared to those with Child's A cirrhosis (P < 0.001). The portal blood flow volume in Child's C cirrhosis were also significantly low compared to patients with Child's A and Child's B cirrhosis (P < 0.001 and P < 0.05, respectively). There was a significant increase in the portal vein congestion index and splenic vein congestion index in patients with Child's C cirrhosis as compared to patients with Child's A cirrhosis (P < 0.001). Among cirrhotic patients, the group with esophageal variceal bleeding had significantly greater splenic blood flow volume and splenic vein congestion index (P < 0.001). Patients with ascites had significantly lower portal flow velocity (P < 0.001) and higher portal vein congestion index and splenic vein congestion index (P = 0.003 and P = 0.05, respectively) as compared to those without ascites. Conclusions. In this report we have shown that the decrease in blood flow and increased congestion indexes in the portal vein and splenic vein are related to the impairment of liver function in cirrhotic patients; these indexes may be valuable factors for predicting esophageal variceal bleeding.en_US
dc.identifier.doi10.1007/s00535-003-1362-xen_US
dc.identifier.endpage667en_US
dc.identifier.issn0944-1174en_US
dc.identifier.issn1435-5922en_US
dc.identifier.issue7en_US
dc.identifier.pmid15293137en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00535-003-1362-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19166
dc.identifier.volume39en_US
dc.identifier.wosWOS:000223043500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER JAPAN KKen_US
dc.relation.ispartofJOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectliver cirrhosisen_US
dc.subjectportal hemodynamicsen_US
dc.subjectsplenic hemodynamicsen_US
dc.subjectesophageal variceal bleedingen_US
dc.subjectDoppler ultrasounden_US
dc.titlePortal and splenic hemodynamics in cirrhotic patients: relationship between esophageal variceal bleeding and the severity of hepatic failureen_US
dc.typeArticleen_US

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