Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits

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dc.contributor.authorCol, R
dc.contributor.authorKeskin, E
dc.contributor.authorAtalay, B
dc.date.accessioned2020-03-26T16:56:56Z
dc.date.available2020-03-26T16:56:56Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPentoxifylline (PTX, a methylxanthine derivative) has been found to interrupt early gene activation for tumour necrosis factor, interleukin-1, interleukin-6 and tissue factor production and to improve survival from experimental sepsis. During endotoxaemia, lipopolysaccharide (LPS, endotoxin) and proinflammatory cytokines trigger the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation. The present study was undertaken to determine whether pentoxifylline could prevent coagulation disturbances in LPS-treated rabbits. Endotoxaemia was induced with E. coli lipopolysaccharide in New Zealand White rabbits. Forty rabbits were used and divided into four equal groups. Group I served as a control group; Group 2: lipopolysaccharide was injected intravenously, Group 3: pentoxifylline was injected intraperitoneally, Group 4: lipopolysaccharide and pentoxifylline were injected simultaneously. Blood samples were collected 6 h after the treatments. In rabbits with endotoxin-induced DIC, platelet count, leukocyte count, percentage of differential leukocyte values, fibrinogen level, antithrombin III (AT-III) and protein C (PC) activity were decreased. Moreover, activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged when compared to the control group. In conclusion, haemostatic disturbances associated with endotoxin-induced DIC were moderately suppressed by the administration of PTX.en_US
dc.identifier.doi10.1556/AVet.53.2005.3.6en_US
dc.identifier.endpage335en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issue3en_US
dc.identifier.pmid16156128en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.53.2005.3.6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19684
dc.identifier.volume53en_US
dc.identifier.wosWOS:000231641800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADOen_US
dc.relation.ispartofACTA VETERINARIA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpentoxifyllineen_US
dc.subjectdisseminated intravascular coagulationen_US
dc.subjectendotoxinen_US
dc.subjectrabbiten_US
dc.titleEffect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbitsen_US
dc.typeArticleen_US

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