Serum galectin-3 levels in women with PCOS

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dc.contributor.authorYılmaz, H.
dc.contributor.authorÇelik, H. T.
dc.contributor.authorÖzdemir, O.
dc.contributor.authorKalkan, D.
dc.contributor.authorNamuslu, M.
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorAtalay, C. R.
dc.date.accessioned2020-03-26T18:58:29Z
dc.date.available2020-03-26T18:58:29Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim Galectin-3 (Gal-3) plays a role in modulation of adiposity, glucose hemostasis and inflammation. The association between Gal-3 and the polycystic ovary syndrome (PCOS), is not investigated. We aimed to evaluate galectin-3 levels in serum and their relation with hyperandrogenism and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and in control subjects. Materials and methods 56 women with PCOS were enrolled along with a control group of 41 healthy women, matched for age and body mass index. We measured hormonal and metabolic parameters, as well as the serum galectin-3 concentration of each participant. We estimated the IR according to the homeostasis model assessment-insulin resistance (HOMA-IR). Results Women with PCOS had higher levels of serum Gal-3 compared to healthy individuals 3,588.77 +/- 1,566.94 vs 2,491.33 +/- 812.04, P < 0.001). Serum Gal-3 levels were correlated with progesterone (r = 0.241, P = 0.025), hirsutism score (r = 0.296, P = 0.006), insulin (r = 0.479, P = 0.028), HOMA-IR (r = 0.514, P = 0.017), dehydroepiandrosterone sulfate (r = 0.246, P = 0.022), testosterone (r = 0.252, P = 0.019), and free testosterone (r = 0.306, P = 0.004). Conclusion Galectin-3 levels are higher in patients with PCOS, and there is a positive correlation between galectin-3 level and IR, androgen levels and hirsutismus scores. Gal-3 may be a new mediator of PCOS via IR, hyperandrogenism.en_US
dc.identifier.doi10.1007/s40618-013-0032-yen_US
dc.identifier.endpage187en_US
dc.identifier.issn1720-8386en_US
dc.identifier.issue2en_US
dc.identifier.pmid24497217en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s40618-013-0032-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31122
dc.identifier.volume37en_US
dc.identifier.wosWOS:000335151700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF ENDOCRINOLOGICAL INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHyperandrogenemiaen_US
dc.subjectPCOSen_US
dc.subjectInsulin resistanceen_US
dc.subjectGalectin-3en_US
dc.titleSerum galectin-3 levels in women with PCOSen_US
dc.typeArticleen_US

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