Pharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbits

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dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.contributor.authorUney, Kamil
dc.contributor.authorEr (Karabacak), Ayse
dc.contributor.authorTras, Buenyamin
dc.date.accessioned2020-03-26T17:27:27Z
dc.date.available2020-03-26T17:27:27Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description10th International Congress of the European-Association-of-Veterinary-Pharmacology-and-Toxicology -- 2006 -- Turin, ITALYen_US
dc.description.abstractThe purpose of this study was to determine the pharmacokinetics and possible interactions of enrofloxacin (ENR) and flunixin meglumine (FM) in healthy rabbits and in rabbits where endotoxaemia had been induced by administering Escherichia coli lipopolysaccharide (LPS). Six male adult New Zealand White rabbits were used for the study. In Phase I, FM (2.2 mg/kg) and ENR (5 mg/kg) were given simultaneously as a bolus intravenous (IV) injection to each healthy rabbit. After a washout period, Phase II consisted of purified LPS administered as an IV bolus injection, then FM and ENR. LPS produced statistically significant increases in some serum biochemical concentrations. After the drugs were co-administered, the kinetic parameters of FM were not significantly different in healthy compared to endotoxaemic rabbits. It is concluded that ENR and FM could be co-administered to rabbits to treat endotoxaemia as no negative interaction was observed between the pharmacokinetics of both drugs. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEuropean Assoc Vet Pharmacol & Toxicolen_US
dc.identifier.doi10.1016/j.tvjl.2007.05.021en_US
dc.identifier.endpage424en_US
dc.identifier.issn1090-0233en_US
dc.identifier.issn1532-2971en_US
dc.identifier.issue3en_US
dc.identifier.pmid17644374en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage418en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.tvjl.2007.05.021
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22565
dc.identifier.volume177en_US
dc.identifier.wosWOS:000258041300019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofVETERINARY JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectendotoxaemiaen_US
dc.subjectenrofloxacinen_US
dc.subjectflunixin meglumineen_US
dc.subjectpharmacokineticsen_US
dc.subjectrabbitsen_US
dc.titlePharmacokinetics of enrofloxacin and flunixin meglumine and interactions between both drugs after intravenous co-administration in healthy and endotoxaemic rabbitsen_US
dc.typeArticleen_US

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