Coenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: Conduction velocity distributions

Basit Öğe Kaydı
dc.contributor.authorAyaz, Murat
dc.contributor.authorTuncer, Seckin
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorGokbel, Hakki
dc.date.accessioned2020-03-26T17:26:30Z
dc.date.available2020-03-26T17:26:30Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDiabetic neuropathies are a family of nerve disorders caused by diabetes. Patients with diabetes can develop nerve problems at any tune, but the longer a person has diabetes the greater the risk. This study aims to investigate diabetes- and coenzyme Q(10) (CoQ(10)) or alpha-lipoic acid (ALA) supplementation-induced changes in the conduction velocity (CV) distributions of rat sciatic nerve fibers. Sciatic nerve compound action potentials (CAPs) were recorded by suction electrode and CV distributions by the collision technique. Diabetes resulted in a significant increase in time to peak, rheobase and chronaxie values of these CAP waveforms, whereas the maximum depolarization, area, kinetics and CVs of both fast and slow nerve fiber groups were found to be decreased, Coenzyme Q(10) (CoQ(10)) supplementation was found to have some positive effect on the diabetes-induced alterations. CoQ(10) supplementation induced positive changes mainly, in the area and fall-down phase of the kinetics of CAP waveforms, as well as rheobase. chronaxie and speed of the intermediately conducting groups (congruent to 40 m/s). alpha-Lipoic acid (ALA) supplementation did not produce statistically significant effects. This stud), has shown for the first tune that diabetes induces a shift of actively contributing nerve fibers toward slower CVs(10) and supplementation with CoQ(10) not only stopped this shift but also tended to restore velocities toward those of the age-matched control group. In addition to its effects on mitochondrial alterations, these positive effects of CoQ(10) on diabetic neuropathy) can be attributed to its antioxidant activity Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [BAP 07202014]en_US
dc.description.sponsorshipThis study was partially supported by the Scientific Research and Project Coordinator of Selcuk University (Fund number: BAP 07202014), Meram, Konya, Turkey.en_US
dc.identifier.doi10.1358/mf.2008.30.5.1186072en_US
dc.identifier.endpage374en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issn2013-0155en_US
dc.identifier.issue5en_US
dc.identifier.pmid18806896en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2008.30.5.1186072
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22257
dc.identifier.volume30en_US
dc.identifier.wosWOS:000259022500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAU-THOMSON REUTERSen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectconduction velocity distributionen_US
dc.subjectcoenzyme Q(10)en_US
dc.subjectalpha-lipoic aciden_US
dc.titleCoenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: Conduction velocity distributionsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu