Nonadrenergic, Noncholinergic Responses of the Human Colon Smooth Muscle and the Role of K+ Channels in These Responses

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dc.contributor.authorŞahin, A. S.
dc.contributor.authorAtalık, K. E.
dc.contributor.authorGünel, E.
dc.contributor.authorDoğan, N.
dc.date.accessioned2020-03-26T16:37:16Z
dc.date.available2020-03-26T16:37:16Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the possible role of notric oxide (NO) as a nonadrenergic, noncholinergic (NANC) mediator in human colon smooth muscle in vitro and to examine its possible interactions with K+ channels. In the presence of atropine (10(-6) M) and guanethidine (10(-5)M).. electrical field stimulation (EFS, 1-10 Hz, 0.3 msec, 50V) for 10 sec induced relaxations which were inhibited by tetrodotoxin (10(-6) M). in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M), relaxations induced by EFS at 1, 2, 4, 8 and 10 Hz were reduced by 38.7 +/- 4.3, 31.5 +/-3.8, 54.3 +/-5.4, 59.8 +/- 4.5 and 68.6 +/- 5.3% respectively. THe relaxations inhibited by L-NAME were restored by the preincubation of L-argarinine (L-ARG, 10(-3) M) at all frequencies tested. D-Arginine (D-ARG, 10(-3) M) had no effect. Tetraethylammonium (TEA, 10(-4) M) or glibenclamidine (10(-6) M) significantly decreased the relaxations induced induced by EFS. Exogenously applied sodium nitroprusside caused concentration-dependent relaxation with prusside. In conclusion, our data indicate that NO is involved in NANC nerve-mediated relaxation in the human calcium-dependent and ATP-sensitive K+ channels.en_US
dc.identifier.doi10.1358/mf.2001.23.1.619174en_US
dc.identifier.endpage17en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue1en_US
dc.identifier.pmid11413858en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2001.23.1.619174
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17578
dc.identifier.volume23en_US
dc.identifier.wosWOS:000169090300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAen_US
dc.relation.ispartofMethods and Findings in Experimental and Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHuman Colonen_US
dc.subjectIn vitroen_US
dc.subjectK+ Channelsen_US
dc.subjectNonadrenergic-Noncholinergic Responsesen_US
dc.titleNonadrenergic, Noncholinergic Responses of the Human Colon Smooth Muscle and the Role of K+ Channels in These Responsesen_US
dc.typeArticleen_US

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