Oxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-Modified Albumin

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dc.contributor.authorMehmetoğlu, İdris
dc.contributor.authorYerlikaya, F. Hümeyra
dc.contributor.authorKurban, Sevil
dc.contributor.authorErdem, S. Sami
dc.contributor.authorTonbul, Zeki
dc.date.accessioned2020-03-26T18:30:59Z
dc.date.available2020-03-26T18:30:59Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q(10)(CoQ(10)) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls. Methods: This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men, 18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ(10) levels were standardized using blood lipids. Results: Serum TAS levels and CoQ(10)/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ(10)/LDL, CoQ(10)/triglycerides, and CoQ(10)/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ(10) levels, and adjusted CoQ(10) values of the CAPD and HD patients. Conclusions: Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ(10) levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested.en_US
dc.identifier.citationMehmetoğlu, İ., Yerlikaya, F. H., Kurban, S., Erdem, S. S., Tonbul, Z., (2012). Oxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-Modified Albumin. International Journal of Artificial Organs, 35(3), 226-232. DOI: 10.5301/ijao.5000078
dc.identifier.doi10.5301/ijao.5000078en_US
dc.identifier.endpage232en_US
dc.identifier.issn0391-3988en_US
dc.identifier.issue3en_US
dc.identifier.pmid22461118en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://dx.doi.org/10.5301/ijao.5000078
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28283
dc.identifier.volume35en_US
dc.identifier.wosWOS:000305443700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMehmetoğlu, İdris
dc.institutionauthorYerlikaya, F. Hümeyra
dc.institutionauthorKurban, Sevil
dc.institutionauthorErdem, S. Sami
dc.institutionauthorTonbul, Zeki
dc.language.isoenen_US
dc.publisherWICHTIG EDITOREen_US
dc.relation.ispartofInternational Journal of Artificial Organsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectContinuous ambulatory peritoneal dialysisen_US
dc.subjectHemodialysisen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectTotal antioxidant statusen_US
dc.subjectTotal oxidant statusen_US
dc.titleOxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-Modified Albuminen_US
dc.typeArticleen_US

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