In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.

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dc.contributor.authorRauf, Abdur
dc.contributor.authorUysal, Sengul
dc.contributor.authorBen Hadda, Taibi
dc.contributor.authorUddin, Ghias
dc.contributor.authorNawaz, Muhammad Asif
dc.contributor.authorKhan, Haroon
dc.contributor.authorSiddiqui, Bina S.
dc.date.accessioned2020-03-26T19:41:53Z
dc.date.available2020-03-26T19:41:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDiospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, antimicrobial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABA(A), GABA(B) and 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10 mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAA but not GABAB and 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications. (C) 2017 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipinstitute of Scientific Research and Revival of Islamic Heritage at Umm Al-Qura University [43410009]en_US
dc.description.sponsorshipThe authors would like to thanks institute of Scientific Research and Revival of Islamic Heritage at Umm Al-Qura University (Project ID 43410009) for financial support.en_US
dc.identifier.doi10.1016/j.biopha.2017.01.021en_US
dc.identifier.endpage682en_US
dc.identifier.issn0753-3322en_US
dc.identifier.issn1950-6007en_US
dc.identifier.pmid28088734en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage678en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2017.01.021
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35201
dc.identifier.volume87en_US
dc.identifier.wosWOS:000395525600079en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofBIOMEDICINE & PHARMACOTHERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMedicinal plantsen_US
dc.subjectDiospyros lotus L.en_US
dc.subject7-methyljugloneen_US
dc.subjectGabaen_US
dc.subjectSedative-hypnotic activityen_US
dc.subjectDocking studyen_US
dc.titleIn vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.en_US
dc.typeArticleen_US

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