The effects of hormone replacement therapy on myocardial performance in early postmenopausal women

Basit Öğe Kaydı
dc.contributor.authorDüzenli, Mehmet Akif
dc.contributor.authorÖzdemir, Kurtuluş
dc.contributor.authorSökmen, A.
dc.contributor.authorGezginç, K.
dc.contributor.authorSoylu, A.
dc.contributor.authorÇelik, C.
dc.contributor.authorAltunkeser, Bülent Behlül
dc.date.accessioned2020-03-26T18:05:16Z
dc.date.available2020-03-26T18:05:16Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMethod In a prospective, controlled study, 60 healthy postmenopausal women were assigned to two groups (32 in the HRT group and 28 in the control group). After conventional echocardiographic parameters were measured, tissue Doppler echocardiography recordings were obtained from the mitral and tricuspid annulus. Systolic myocardial velocity (Sm), early and late diastolic myocardial velocities (Em and Am) and time intervals were measured and MPI was calculated. Then the symptom-limited exercise stress test using the Bruce protocol was performed. After 3 and 6 months of HRT (oral 0.625 mg conjugated estrogen + 2.5 mg medroxyprogesterone acetate/day), the same examinations were repeated. The effects of HRT on myocardial velocities, MPI and exercise time were evaluated at the 3rd and 6th months. Results The parameters of the control group remained statistically unchanged during the study. HRT did not have any effect on segmental and mean left ventricular (LV) Sm or right ventricular (RV) Sm. However, LV Em/Am and RV Em/Am ratios significantly increased at the 6th month of HRT, and LV and RV MPI values were observed to decrease significantly as compared to basal values. Additionally, a significant increase was observed in exercise duration and metabolic equivalent values after 3 months of HRT, and this increase continued at the 6th month as well. The favorable changes in all parameters in the HRT group were significantly different from those of the control group. Conclusion Data obtained in this study suggest that HRT is not only effective for treating menopausal complaints but also increases cardiovascular performance by improving especially diastolic functions in early postmenopausal women.en_US
dc.identifier.doi10.3109/13697130902929567en_US
dc.identifier.endpage170en_US
dc.identifier.issn1369-7137en_US
dc.identifier.issn1473-0804en_US
dc.identifier.issue2en_US
dc.identifier.pmid19672733en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://dx.doi.org/10.3109/13697130902929567
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25368
dc.identifier.volume13en_US
dc.identifier.wosWOS:000274905600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofCLIMACTERICen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMYOCARDIAL PERFORMANCE INDEXen_US
dc.subjectHORMONE REPLACEMENT THERAPYen_US
dc.subjectTISSUE DOPPLER ECHOCARDIOGRAPHYen_US
dc.subjectEXERCISE STRESS TESTen_US
dc.titleThe effects of hormone replacement therapy on myocardial performance in early postmenopausal womenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu