Levels of cardiac biomarkers and coagulation profiles in dogs with parvoviral enteritis

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dc.contributor.authorCenk, E. R.
dc.contributor.authorMahmut, O. K.
dc.date.accessioned2020-03-26T19:06:16Z
dc.date.available2020-03-26T19:06:16Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractThe first aim of this study is to determine the changes of cardiac biomarkers and coagulation profiles in parvoviral enteritis and present the importance of these parametres for prognosis of the disease. The second aim is to determine the presence of myocarditis in the enteritis form of the disease via cardiac biomarkers. Twenty seven dogs with parvoviral enteritis (experiment group) and 6 healthy dogs (control group) which were aged between 1.5 and 6 months, weighted between 5 - 15 kg were used as a material of this study. Anorexia, fever, depression, lethargy, vomitting and haemorrhagic diarrhea were determined in dogs with parvoviral enteritis. Parvovirus infection in dogs were verified via feces parvovirus antigen test. Blood samples were collected from all dogs and electrocardiographies (ECG's) were performed. Standard treatment is applied for dogs with parvoviral enteritis. Twenty three of these dogs were treated successfully; however four of them died. Mild to intermediate acute myocarditis were determined in the histopathological examination of the dead dogs. Plasma protrombin (PT), actived parsiel tromboplastin time (aPTT), antitrombin III (AT-III), fibrinogen and D-dimer concentrations and serum creatin kinase-MB (CK-MB), cardiac troponin I (cTnI) and brain natriuretic peptid (BNP) concentrations were measured. Increase in levels of plasma PT (P<0.001) and aPTT (P<0.001), fibrinogen (P<0.001) and D-dimer (P<0.05), and decrease in level of III AT-III (P<0.05) were detected in dogs with parvoviral enteritis. Increased level of serum CK-MB (P<0.05) and BNP (P<0.001) were also determined. No important change detected in serum cTnI levels. As results, in dogs with parvoviral enterit there were increase in PT, APTT, fibrinogen and D-dimer levels, on the other hand there was a decrease on AT III level resulting in DIC. In addition to this an increase was observed on plasma serum CK-MB and BNP levels. Considering the increase on CK-MB and BNP levels a long with results of histopathological dead dogs, it should be taken into account that acute miocarditis also occures simultaneous with hemoragic parvoviral enterit.en_US
dc.description.sponsorshipSelcuk University Coordinates of Scientific Research ProjectsSelcuk University [11102015]en_US
dc.description.sponsorshipThis study was funded by Selcuk University Coordinates of Scientific Research Projects (Project No: 11102015)Een_US
dc.identifier.citationEr, C., Ok, M. (2015). Levels of Cardiac Biomarkers and Coagulation Profiles in Dogs with Parvoviral Enteritis. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 21(3), 383-388.
dc.identifier.doi10.9775/kvfd.2014.12575en_US
dc.identifier.endpage388en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2014.12575
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32297
dc.identifier.volume21en_US
dc.identifier.wosWOS:000354410400014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCenk, E. R.
dc.institutionauthorMahmut, O. K.
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDogen_US
dc.subjectCardiac biomarkersen_US
dc.subjectParvoviral Enteritisen_US
dc.subjectCoagulation profileen_US
dc.titleLevels of cardiac biomarkers and coagulation profiles in dogs with parvoviral enteritisen_US
dc.typeArticleen_US

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