Paclitaxel Resistance in MCF-7/Pac Cell Line is Reversed Successfully by Saikosaponin A and Saikosaponin D

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dc.contributor.authorKars, Meltem D.
dc.contributor.authorKars, Gokhan
dc.contributor.authorGunduz, Ufuk
dc.date.accessioned2020-03-26T18:42:48Z
dc.date.available2020-03-26T18:42:48Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCancer cells demonstrate multiple drug resistance phenotype frequently after chemotherapy. The resistance of cancer cells to various chemotherapeutic agents is defined as multiple drug resistance. The purpose of this study is to investigate the potential reversal effects of active agents, that are found high amount in plants, on resistant MCF-7 cell lines. The effects of potential MDR modulators combined with anticancer drugs were also evaluated. Flow cytometry, fluorescence microscopy and checkerboard combination assays were performed to study the reversal of drug resistance and for investigation of the antiproliferative effects of the combination of anticancer drugs with the modulators. Paclitaxel and potential MDR modulators (verapamil, saikosaponin A, D and isoquercitrin) were applied to the sublines in combination. Fluorescence accumulation levels and fractional inhibitory indices show that saikosaponin A and D are effective MDR reversal agents that may be used together with paclitaxel in drug resistant mammary carcinoma subline. In conclusion this report represents saikosaponin A and D from natural resources are valuable reagents that may improve the success of chemotherapy.en_US
dc.description.sponsorshipTUBITAK projectTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [110T552]en_US
dc.description.sponsorshipThis study was supported by a TUBITAK project (110T552).en_US
dc.identifier.doi10.4999/uhod.13009en_US
dc.identifier.endpage232en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://dx.doi.org/10.4999/uhod.13009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29710
dc.identifier.volume23en_US
dc.identifier.wosWOS:000329334500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMDRen_US
dc.subjectMCF-7en_US
dc.subjectMDR reversalen_US
dc.subjectSaikosaponinsen_US
dc.subjectCheckerboard microplate methoden_US
dc.titlePaclitaxel Resistance in MCF-7/Pac Cell Line is Reversed Successfully by Saikosaponin A and Saikosaponin Den_US
dc.typeArticleen_US

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