Preoperative analgesia management with rofecoxib in thoracotomy patients

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dc.contributor.authorCelik, JB
dc.contributor.authorGormus, N
dc.contributor.authorGormus, ZI
dc.contributor.authorOkesli, S
dc.contributor.authorSolak, H
dc.date.accessioned2020-03-26T16:57:46Z
dc.date.available2020-03-26T16:57:46Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Pain management after thoracotomy is significant because pain reduces the postoperative respiratory performance. In this study, the analgesic efficacy and safety of rofecoxib in thoracotomy patients were evaluated. Design: A prospective, randomized, double-blind, and placebo-controlled study. Setting: This study was performed in the Meram Medical School of Selcuk University Departments of Cardiovascular Surgery and Anesthesiology. Participants: Sixty patients undergoing elective thoracic surgery via thoracotomy were randomized to receive either oral placebo or rofecoxib, 50 mg, 1 hour before surgery. Interventions: All patients received a standard anesthetic. Pain scores, sedation scores, heart rate, mean arterial pressure, respiratory rate, analgesic requirements, and side effects were noted 2, 4, 8,12, 18, 24, 32, 40, and 48 hours after operation. Measurements and Main Results:There were no significant differences between the 2 study groups with respect to demographics, sedation score, intraoperative blood loss, and postoperative drainage. Compared with placebo, morphine consumption and pain scores at rest and during coughing were significantly lower with rofecoxib. Conclusions: The preoperative administration of rofecoxib, 50 mg, provides significant analgesia for postoperative pain relief and decreases additional opioid requirements after thoracotomy. (C) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1053/j.jvca.2004.11.012en_US
dc.identifier.endpage70en_US
dc.identifier.issn1053-0770en_US
dc.identifier.issue1en_US
dc.identifier.pmid15747272en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://dx.doi.org/10.1053/j.jvca.2004.11.012
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19844
dc.identifier.volume19en_US
dc.identifier.wosWOS:000227359900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS COen_US
dc.relation.ispartofJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpreemptive analgesiaen_US
dc.subjectcyclooxygenase-2 selective inhibitorsen_US
dc.subjectrofecoxiben_US
dc.subjectpostoperative painen_US
dc.titlePreoperative analgesia management with rofecoxib in thoracotomy patientsen_US
dc.typeArticleen_US

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