Influence of Escherichia coli endotoxin-induced endotoxaemia on the pharmacokinetics of enrofloxacin after intravenous administration in rabbits

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dc.contributor.authorElmas, M.
dc.contributor.authorYazar, E.
dc.contributor.authorUney, K.
dc.contributor.authorEr (Karabacak), A.
dc.date.accessioned2020-03-26T17:03:44Z
dc.date.available2020-03-26T17:03:44Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe main goal of present study was to determine the effects of an Escherichia coli endotoxin-induced endotoxaemic status on disposition of enrofloxacin after a single intravenous dose (5 mg/kg) in rabbits. Septic shock was induced by the i.v. bolus administration at a single dose of E. coli lipopolysaccharide. Six adult New Zealand White rabbits were used. Concentrations of drug in plasma were determined by HPLC. The plasma pharmacokinetic values for enrofloxacin were best represented using a two-Compartment open model. Total plasma clearance (Cl-T) decreased from 2.11 (l/h/kg) in healthy animals to 1.50 (l/h/kg) in rabbits with septic shock, which is related to an increase in the AUCO(0 -> infinity). In endotoxaemic rabbits, volume of distribution at steady state (V-dss = 3.61 l/kg) was significantly lower (P < 0.05) than in healthy animals (V-dss = 4.97 l/kg). However, the elimination half-life of enrofloxacin was not affected by lipopolysaccharide administration.en_US
dc.identifier.doi10.1111/j.1439-0442.2006.00854.xen_US
dc.identifier.endpage414en_US
dc.identifier.issn0931-184Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid16970630en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage410en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1439-0442.2006.00854.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20543
dc.identifier.volume53en_US
dc.identifier.wosWOS:000241282100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleInfluence of Escherichia coli endotoxin-induced endotoxaemia on the pharmacokinetics of enrofloxacin after intravenous administration in rabbitsen_US
dc.typeArticleen_US

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