The Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgery

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dc.contributor.authorOç, Bahar
dc.contributor.authorAkıncı, Seda B.
dc.contributor.authorKanbak, Meral
dc.contributor.authorSatana, Eda
dc.contributor.authorÇelebioğlu, Bilge
dc.contributor.authorAypar, Ülkü
dc.date.accessioned2020-03-26T18:31:43Z
dc.date.available2020-03-26T18:31:43Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: There are few data on the effects of anesthesia and cardiopulmonary bypass (CPB) on perioperative renal function in children with cyanotic congenital heart disease undergoing open heart surgery. This study aims to investigate the perioperative renal function in cyanotic versus acyanotic children undergoing sevoflurane anesthesia for open heart surgery. Methods: After receiving ethical committee approval, 12 acyanotic patients (preoperative oxygen saturation: SaO(2) > 85%) and 12 cyanotic children (SaO(2) < 85%) were included. Sevoflurane was administered at concentration levels of 2% before CPB and 1-2% during CPB after standard anesthesia induction. Inorganic fluoride, electrolytes, creatinine, urea nitrogen in serum and urine samples, and N-acetyl-beta-D-glucosaminidase (NAG) in urine samples were measured before induction, before CPB, during CPB, after CPB, at the end of surgery, and at 24th h postoperatively. Results: The levels of serum uric acid levels were higher in the cyanotic group (p < 0.05). There were no differences in the levels of serum creatinine and urine creatinine, urea nitrogen, and electrolytes between the two groups. Serum inorganic fluoride levels were always higher in the acyanotic group than in the cyanotic group, but these differences between the groups reached statistical significance at two measurement times (before CPB and end of surgery) (p < 0.05). Urinary inorganic fluoride levels increased with time in both groups. Although urinary NAG increased significantly after the CPB in the cyanotic group, the differences between the two groups did not reach statistical significance. Conclusions: We have concluded that renal function was not affected during open heart surgery with sevoflurane anesthesia, in both cyanotic and acyanotic children.en_US
dc.description.sponsorshipDepartment of Anesthesiology and Reanimation, Hacettepe University Faculty of MedicineHacettepe Universityen_US
dc.description.sponsorshipThis study was financially supported by the Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine.en_US
dc.identifier.doi10.3109/0886022X.2011.641513en_US
dc.identifier.endpage141en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issn1525-6049en_US
dc.identifier.issue2en_US
dc.identifier.pmid22150502en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2011.641513
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28518
dc.identifier.volume34en_US
dc.identifier.wosWOS:000299784400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectrenal functionen_US
dc.subjectcongenital heart diseaseen_US
dc.subjectchildrenen_US
dc.subjectopen heart surgeryen_US
dc.subjectsevofluraneen_US
dc.titleThe Effects of Sevoflurane Anesthesia and Cardiopulmonary Bypass on Renal Function in Cyanotic and Acyanotic Children Undergoing Cardiac Surgeryen_US
dc.typeArticleen_US

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