Correlation Between Down Syndrome and the Level of Placental Alkaline Phosphatase in Amniotic Fluid

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dc.contributor.authorUçar, Canan
dc.contributor.authorBalcı, Sevim
dc.contributor.authorTunçbilek, Ergül
dc.contributor.authorÜnsal, İbrahim
dc.date.accessioned2020-03-26T16:58:44Z
dc.date.available2020-03-26T16:58:44Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the correlation between Down syndrome and the level of placental alkaline phosphatase (PLAP) in amniotic fluid. A total of 279 amniotic fluid samples taken between 14 and 24 gestational weeks were investigated in this study. Karyotype analysis was made in all samples. In 10 samples trisomy 21 was determined, in one sample trisomy 18, in two samples 47,XXY, in six samples various structural chromosomal anomalies and in 260 samples normal karyotype. PLAP was measured using a fluorometric heat inactivation assay. Mean PLAP multiples of normal gestational median (MOM) value in samples with Down syndrome was 0.44 MOM, and in those with normal karyotype was 1.14 MOM. In fetuses with Down syndrome, amniotic fluid PLAP levels were significantly reduced (p = 0.002). There was no difference between mean PLAP MOM values in samples with normal karyotype and in those with structural chromosomal abnormality (p = 0.47). When 0.37 MOM was accepted as a cut-off value of PLAP activity in amniotic fluid, detection rate (sensitivity) of the test was 50%, specificity was 94%, and false-positive rate was 5.8%. We conclude that PLAP levels are reduced in the amniotic fluid of women carrying a fetus with Down syndrome.en_US
dc.identifier.citationUçar, C., Balcı, S., Tunçbilek, E., Ünsal, İ., (2005). Correlation Between Down Syndrome and the Level of Placental Alkaline Phosphatase in Amniotic Fluid. Turkish Journal of Medical Sciences, 35(5), 310-316.
dc.identifier.endpage316en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20006
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAmniotic fluiden_US
dc.subjectDown syndromeen_US
dc.subjectPLAP (placental alkaline phosphatase)en_US
dc.titleCorrelation Between Down Syndrome and the Level of Placental Alkaline Phosphatase in Amniotic Fluiden_US
dc.typeArticleen_US

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