Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract

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dc.contributor.authorEruygur, N.
dc.contributor.authorKoçyiğit, U. M.
dc.contributor.authorTaslimi, P.
dc.contributor.authorAtaş, M.
dc.contributor.authorTekin, M.
dc.contributor.authorGülçin, I.
dc.date.accessioned2020-03-26T20:19:15Z
dc.date.available2020-03-26T20:19:15Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractThe Achillea genus belongs to the Asteraceae family, which is mostly found in the northern hemisphere and is comprised of 115 species in the world. In Turkish flora, there are 52 species and 58 taxa, among them half of which are recorded as endemic. To the best of our knowledge, there has been no biological activity studied in this species until now, with the exception of one study of the antimicrobial activity of certain essential oils. This study focused primarily on the determination of antioxidant, antimicrobial, and enzyme-inhibition activity of aqueous ethanol extract of Turkish endemic Achillea cucullata by in vitro methods. The extract exhibited DPPH radical scavenging activity with an IC50 value of 132.55 +/- 0.026 mu g/mL, the total phenol content was 53.807 +/- 0.059 (mg GAE/g), and the total flavonoid content was 21.372 +/- 0.026 (mg QE/g), on the dry-weight basis. Antimicrobial activity was evaluated by a micro-dilution method focused on five microorganisms; two Gram-positive [Staphylococcus aureus (ATCC 29213) and Enterococcus faecalis (ATCC 29212)], two Gram-negative [Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (ATCC 25922)], and one fungal strain [Candida albicans (ATCC 10231)]. Results show that the MIC value for the tested microorganism was higher than 5 mg/mL. In this work, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase enzymes were strongly inhibited by the A. cucullata extract, and the IC50 values for these enzymes were 2.4 mu g/mL, 0.26 mu g/mL, and 24.75 mu g/mL, respectively. Certain acetylcholinesterase inhibitors have been used for treatment of Alzheimer's disease in the past. alpha-Glucosidase inhibitors are strong drug candidates, as well as potential functional food agents, for deferring the postprandial absorbency of glucose. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.citationEruygur, N., Koçyiğit, U. M., Taslimi, P., Ataş, M., Tekin, M., Gülçin, İ. (2019). Screening the in vitro Antioxidant, Antimicrobial, Anticholinesterase, Antidiabetic Activities of Endemic Achillea cucullata (Asteraceae) Ethanol Extract. South African Journal of Botany, 120, 141-145.
dc.identifier.doi10.1016/j.sajb.2018.04.001en_US
dc.identifier.endpage145en_US
dc.identifier.issn0254-6299en_US
dc.identifier.issn1727-9321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.sajb.2018.04.001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38178
dc.identifier.volume120en_US
dc.identifier.wosWOS:000456314600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorEruygur, N.
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofSOUTH AFRICAN JOURNAL OF BOTANYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAchillea cucullataen_US
dc.subjectAntioxidant activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectAntidiabetic activityen_US
dc.titleScreening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extracten_US
dc.typeArticleen_US

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