Evaluation of death pathway genes FAS and FASL polymorphisms in chronic HBV infection

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dc.contributor.authorZamani, A. G.
dc.contributor.authorBarlas, I. O.
dc.contributor.authorDurakbasi-Dursun, G.
dc.contributor.authorUral, O.
dc.contributor.authorErdal, E.
dc.contributor.authorYildirim, M. S.
dc.date.accessioned2020-03-26T18:41:50Z
dc.date.available2020-03-26T18:41:50Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was designed to determine the possible asssociation between selected FAS and FASLG polymorphisms and Hepatitis B virus (HBV) infection. FAS-670 G/A, FAS-1377 G/A, FASLG-844 T/C and FASLGIVS2nt-124 A/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of age and sex matched 108 controls and a hundred chronic HBV patients were recruited to conduct a case-control study. FAS-670 polymorphism was associated with chronic HBV infection (P=0.03) FAS-1377 GG, GA and AA genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; P=0.00). FASLG-844 allele distribution was similar between the groups (P=0.17) but TC genotype (67.3%) was frequent in chronic HBV patients, while CC genotype was found significantly higher (29.6%) in controls. No association between FASLGIVS2nt-124 polymorphism and chronic HBV infection could be identified (P=0.55). FAS-670 polymorphism is associated with chronic HBV infection, while FASLGIVS2nt-124 A/G polymorphism is not. The FAS-1377G/A and FASLG-844 T/C genotypes are likely to play a substantial role in HBV infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV infection.en_US
dc.description.sponsorshipRoche Mustahzarlar Sanayi Anonim Sirketi, Istanbul, TURKEYen_US
dc.description.sponsorshipThis study was supported by 'Roche Mustahzarlar Sanayi Anonim Sirketi, Istanbul, TURKEY'.en_US
dc.identifier.doi10.1111/iji.12056en_US
dc.identifier.endpage487en_US
dc.identifier.issn1744-3121en_US
dc.identifier.issn1744-313Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid23560484en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage482en_US
dc.identifier.urihttps://dx.doi.org/10.1111/iji.12056
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29481
dc.identifier.volume40en_US
dc.identifier.wosWOS:000326967900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMMUNOGENETICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEvaluation of death pathway genes FAS and FASL polymorphisms in chronic HBV infectionen_US
dc.typeArticleen_US

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