Influences of flunixin and tenoxicam on the pharmacokinetics of florfenicol in lipopolysaccharide-induced endotoxemia

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dc.contributor.authorKoc, Feride
dc.contributor.authorAtila, Alptug
dc.contributor.authorKarakus, Emre
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T19:06:09Z
dc.date.available2020-03-26T19:06:09Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the influences of flunixin (FM) and tenoxicam (TN) on the pharmacokinetics of florfenicol (FF) after coadministration in lipopolysaccharide (LPS)-induced endotoxemic rabbits. Fifteen male rabbits were used in this study. FF (20 mg/kg), FM (2 mg/kg), and TN (1 mg/kg) were coadministered via intravenous injection to the animals. The concentrations of FF were determined by high-performance liquid chromatography with diode-array detection from 0.08 to 12 h in plasma. The plasma concentration-time profile of FF was described using a noncompartmental open model. In this study, terminal half-life, area under the curve, mean residence time, and volume of distribution at steady state were significantly increased, whereas total body clearance was decreased in coadministered groups. In conclusion, FM and TN have effects on the pharmacokinetics of FF in coadministered endotoxemic rabbits. When FF is coadministered with FM and TN, it can be given at a dose of 20 mg/kg b.w. every 8 h for treatment of infections caused by susceptible pathogens with a minimum inhibitory concentration (MIC) of <= 2 mu g/mL or 12 h for treatment of infections caused by susceptible pathogens with MIC of <= 1 mu g/mL in critically ill rabbits. Further studies are necessary to determine variations in dosage regimens.en_US
dc.description.sponsorshipAtaturk University, Erzurum, Turkey (Veterinary Faculty and Experimental Research Center)Ataturk Universityen_US
dc.description.sponsorshipWe thank Ataturk University, Erzurum, Turkey (Veterinary Faculty and Experimental Research Center) for its support.en_US
dc.identifier.doi10.3906/vet-1411-57en_US
dc.identifier.endpage173en_US
dc.identifier.issn1300-0128en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://dx.doi.org/10.3906/vet-1411-57
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32242
dc.identifier.volume39en_US
dc.identifier.wosWOS:000353338100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherSCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAKen_US
dc.relation.ispartofTURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPharmacokineticsen_US
dc.subjectflorfenicolen_US
dc.subjectrabbiten_US
dc.subjectflunixinen_US
dc.subjecttenoxicamen_US
dc.subjectlipopolysaccharideen_US
dc.titleInfluences of flunixin and tenoxicam on the pharmacokinetics of florfenicol in lipopolysaccharide-induced endotoxemiaen_US
dc.typeArticleen_US

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