The Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injury

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dc.contributor.authorCaliskan, Merve
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMenevse, Esma
dc.date.accessioned2020-03-26T19:26:49Z
dc.date.available2020-03-26T19:26:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF. Blood samples and serebral cortex were analysed for malondyaldehyde (MDA), NO (nitric oxide), xanthine oxidase (XO), glutathione (GSH) and glutathione peroxidase (GPx). Blood MDA levels were significantly higher ischemia-reperfusion groups (P < 0.005). However, DiOHF inhibited MDA. Ischemia-reperfusion led to increased XO and NO but DiOHF supplementation reduced NO and XO. DiOHF increased GSH and GPx levels compared to ischemia-reperfusion group. All together, our present study showed that intraperitoneal DiOHF supplementation has protective effect on brain ischaemia-reperfusion injury in rat.en_US
dc.description.sponsorshipSelcuk University, Scientific Research CouncilSelcuk University [14202015]en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant Number is 14202015).en_US
dc.identifier.doi10.1007/s11064-016-1889-xen_US
dc.identifier.endpage1740en_US
dc.identifier.issn0364-3190en_US
dc.identifier.issn1573-6903en_US
dc.identifier.issue7en_US
dc.identifier.pmid27017510en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1732en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11064-016-1889-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34060
dc.identifier.volume41en_US
dc.identifier.wosWOS:000377474000022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER/PLENUM PUBLISHERSen_US
dc.relation.ispartofNEUROCHEMICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrain ischaemia-reperfusionen_US
dc.subject3 ',4 '-dihydroxyflavonolen_US
dc.subjectFree radicalsen_US
dc.subjectRaten_US
dc.titleThe Effect of 3 ',4 '-Dihydroxyflavonol on Lipid Peroxidation in Rats with Cerebral Ischemia Reperfusion Injuryen_US
dc.typeArticleen_US

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