Evaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findings

Basit Öğe Kaydı
dc.authorid0000-0001-7679-6568
dc.contributor.authorTopcu Yilmaz, Pinar.
dc.contributor.authorAydin, Memduha.
dc.contributor.authorIlhan, Bilge Cetin.
dc.date.accessioned2020-03-26T20:14:05Z
dc.date.available2020-03-26T20:14:05Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVES: The study was performed to evaluate the retinal nerve fiber layer (RNFL), macular, and subfoveal choroidal thickness (SFCT) in patients with schizophrenia and healthy controls using spectral domain optical coherence tomography (SD-OCT). METHODS: Fifty-nine schizophrenic patients and 36 age- and sex-matched healthy volunteers were enrolled in this cross-sectional clinical study. The RNFL, macular, and SFCT thickness measurements obtained by SD-OCT were compared between the groups. RESULTS: The mean age of 59 patients included in this study was 34.64 years and the mean age of 36 healthy controls was 32.08 years, mean illness duration was 10.33 years, mean total Positive and Negative Symptom Scale (PANSS) score was 75.18, and mean CGI-S score was 3.88. Macular thickness in the superior inner (350.97 +/- 16.51 vs. 341.81 +/- 16.35), nasal inner (348.97 +/- 17.53 vs. 340.25 +/- 17.55), inferior inner (345.5 +/- 17.59 vs. 335.47 +/- 16.92), temporal inner (333.28 +/- 17.96 vs. 321.97 +/- 19.96), and temporal outer (289.14 +/- 14.10 vs. 281.29 +/- 15.31) segments were significantly decreased in schizophrenic patients. However; RNFL thickness and choroidal thickness (CT) measurements between the two groups were similar. No significant correlation was found between illness duration, PANSS score, CGI-S score and RNFL thickness and macular thickness measurements. There was a weak negative correlation between disease duration and CT. CONCLUSIONS: The findings from this study suggest that macular thickness measurements are reduced in schizophrenic patients but do not indicate any significant change in RNFL or choroids. Further studies are needed to determine the potential application of optical coherence tomography as a tool for the diagnosis and monitoring the progression of this disease.en_US
dc.identifier.citationYilmaz, P. T., Aydin, M., Ilhan, B. C. (2019). Evaluation of Retinal Nerve Fiber Layer, Macular, and Choroidal Thickness in Schizophrenia: Spectral Optic Coherence Tomography Findings. Psychiatry and Clinical Psychopharmacology, 29(1), 28-33.
dc.identifier.doi10.1080/24750573.2018.1426693en_US
dc.identifier.endpage33en_US
dc.identifier.issn2475-0573en_US
dc.identifier.issn2475-0581en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://dx.doi.org/10.1080/24750573.2018.1426693
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37816
dc.identifier.volume29en_US
dc.identifier.wosWOS:000461499800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAydin, Memduha.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofPSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChoroidal thicknessen_US
dc.subjectmacular thicknessen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectretinal nerve fiber layer thicknessen_US
dc.subjectschizophreniaen_US
dc.titleEvaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findingsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Pinar Topcu YILMAZ.pdf
Boyut:
1.03 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Ruh Sağlığı ve Hastalıkları/Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu