In vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae)

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dc.contributor.authorCastaneda-Loaiza, Viana
dc.contributor.authorPlacines, Chloe
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorPereira, Catarina G.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorNeng, Nuno R.
dc.contributor.authorNogueira, Jose M. F.
dc.date.accessioned2020-03-26T20:20:19Z
dc.date.available2020-03-26T20:20:19Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis work reports for the first time the in vitro anti-oxidant (towards DPPH, ABTS, copper and iron), enzymatic inhibitory (on AChE, BuChE, alpha-glucosidase, alpha-amylase and tyrosinase), cytotoxicity (towards HepG2 and HEK 293 cells), and metabolomics (by HPLC-MS) of extracts from organs of Malcolmia littorea (L.) R.Br. Extracts were constituted mainly by phenolic acids and flavonoids, and main compounds were salicylic acid and luteolin-7-O-glucoside. Samples showed reduced radical scavenging and metal chelating capacity, and only the methanol extracts reduced iron. The root's ethanol and methanol extracts, and the aerial organ's ethanol extract exhibited the highest AChE inhibition. The root's ethanol extract displayed dual anti-cholinesterase activity. Samples showed a low capacity to inhibit alpha-amylase, but a high alpha-glucosidase inhibition was obtained with the root's and flower's ethanol extracts, and flower's methanol extract. Overall, samples displayed a high inhibition against tyrosinase, reduced HepG2 cellular viability and were less toxic towards HEK 293 cells.en_US
dc.description.sponsorshipFoundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology; Portuguese National Budget [CCMAR/Multi/04326/2019, UID/DTP/04138/2019, ALG-01-0145-FEDER-028876]; FCTPortuguese Foundation for Science and Technology [SFRH/BD/116604/2016, CEECIND/00425/2017]en_US
dc.description.sponsorshipWork funded by the Foundation for Science and Technology (FCT) and the Portuguese National Budget (CCMAR/Multi/04326/2019, UID/DTP/04138/2019, ALG-01-0145-FEDER-028876 projects). M.J.R. and L.C. acknowledge FCT for SFRH/BD/116604/2016 and CEECIND/00425/2017.en_US
dc.identifier.citationCastaneda-Loaiza, V., Placines, C., Rodrigues, M.J., Pereira, C.G., Zengin, G., Neng, N.R., Nogueira, J.M.F. (2020). In Vitro Enzyme Inhibitory and Anti-Oxidant Properties, Cytotoxicity and Chemical Composition of the Halophyte Malcolmia Littorea (L.) R.Br. (Brassicaceae). Natural Product Research, 34.
dc.identifier.doi10.1080/14786419.2020.1719484en_US
dc.identifier.issn1478-6419en_US
dc.identifier.issn1478-6427en_US
dc.identifier.pmid32013559en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14786419.2020.1719484
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38559
dc.identifier.wosWOS:000512555100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNATURAL PRODUCT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPhytochemicalsen_US
dc.subjecttyrosinase inhibitorsen_US
dc.subjectcholinesterase inhibitorsen_US
dc.subjectsalt tolerant plantsen_US
dc.titleIn vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae)en_US
dc.typeArticleen_US

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