Effects of Deferoxamine on Tissue Lactate and Malondialdehyde Levels in Cerebral Ischemia

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dc.contributor.authorBarışkaner, Hülagü
dc.contributor.authorÜstün, M. E.
dc.contributor.authorAk, A.
dc.contributor.authorYosunkaya, Alper
dc.contributor.authorDoğan, N.
dc.contributor.authorGürbilek, Mehmet
dc.date.accessioned2020-03-26T16:45:39Z
dc.date.available2020-03-26T16:45:39Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia at rabbits was studied. Rabbits were divided equally, into three groups: group 1: sham-operated group; group 2: cerebral ischemia produced by clamping bilateral common carotid arteries for 60 min: and group 3: deferoxamine 100 mg/kg i.v administered within 5 min after opening the clamps. EEG recordings were obtained in all groups before clamping and in group 2 and 3 60 min after clamping and 60 min after opening the clamps. One hour after opening the clamps and taking EEG recordings, brain cortices were resected and the concentrations of lactate and MDA were determined using the spectrophotometric enzymatic and thiobarbituric acid methods, respectively. There were significant differences between group I and the other groups in MDA and lactate levels (p < 0.05). There were no significant differences in lactate levels between groups 2 and 3. Preischemic EEG grades were the same at till groups. Preischemic (aid postischemic EEG values were significantly different (p < 0.05), but there were no significant differences between postischemic EEG grades in groups 2 and 3. There was also a correlation between postischemic EEG grades and lactate levels, but no correlation between postischemic EEG grades and MDA levels. These results demonstrate that cerebral ischemia leads to an increase in brain tissue lactate and MDA levels and deferoxamine suppresses the increase of MDA, but not lactate. Deferoxamine treatment caused no significant EEG changes. EEG grades correlated well with lactate levels.en_US
dc.identifier.citationBarışkaner, H., Üstün, M. E., Ak, A., Yosunkaya, A., Doğan, N., Gürbilek, M., (2003). Effects of Deferoxamine on Tissue Lactate and Malondialdehyde Levels in Cerebral Ischemia. Methods and Findings in Experimental and Clinical Pharmacology, 25(5), 371-376. Doi: 10.1358/mf.2003.25.5.769659
dc.identifier.doi10.1358/mf.2003.25.5.769659en_US
dc.identifier.endpage376en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issue5en_US
dc.identifier.pmid12851660en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2003.25.5.769659
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18445
dc.identifier.volume25en_US
dc.identifier.wosWOS:000184245800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProus Science, Sa en_US
dc.relation.ispartofMethods and Findings in Experimental and Clinical Pharmacology en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCerebral Ischemiaen_US
dc.subjectDeferoxamineen_US
dc.subjectLactateen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMalondialdehydeen_US
dc.titleEffects of Deferoxamine on Tissue Lactate and Malondialdehyde Levels in Cerebral Ischemia en_US
dc.typeArticleen_US

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