Central arterial characteristics of gout patients with chronic kidney diseases

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorYilmaz, Sema
dc.contributor.authorKebapcilar, Levent
dc.contributor.authorGundogdu, Ali
dc.date.accessioned2020-03-26T19:34:14Z
dc.date.available2020-03-26T19:34:14Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the relationship between central blood pressure, arterial stiffness parameters and renal function parameters in gout patients with chronic kidney disease (CKD) and without CKD. Methods: The study enrolled 48 gout patients and 32 control subjects. Central blood pressure, arterial stiffness parameters and renal function parameters in gout patients were investigated. The vascular measurements were performed with an arteriograph. Results: Of the gout patients, 40.1% had CKD. The 24-h pulse pressure (PP) (P < 0.001), central systolic blood pressure (SBP) (P < 0.001), central diastolic blood pressure (DBP) (P < 0.001), cardiac output (CO) (P < 0.001) and peripheral resistance (P = 0.004) were significantly higher in the all patients with gout compared to healthy control subjects. Moreover, when the gout patients with and without CKD were compared, the gout patients with CKD had higher 24-h PP (P = 0.009), 24-h augmentation index standardized to a heart rate of 75 beats per min (AIx@75) (P < 0.023), daytime PP (P = 0.001), daytime AIx@75 (P = 0.027), and nighttime PP (P = 0.035) than the gout patients without CKD. Conclusions: In our study, gout patients with CKD had worse and more emphasized evidence of arterial stiffness than gout patients without CKD. Further investigations with large sample sizes are needed to evaluate the effect of CKD on the arterial stiffness of gout patients.en_US
dc.identifier.doi10.1111/1756-185X.12689en_US
dc.identifier.endpage638en_US
dc.identifier.issn1756-1841en_US
dc.identifier.issn1756-185Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid26176346en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage628en_US
dc.identifier.urihttps://dx.doi.org/10.1111/1756-185X.12689
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34863
dc.identifier.volume20en_US
dc.identifier.wosWOS:000405269400015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF RHEUMATIC DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalbuminuriaen_US
dc.subjectaugmentation indexen_US
dc.subjectcentral blood pressuresen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectgout diseaseen_US
dc.titleCentral arterial characteristics of gout patients with chronic kidney diseasesen_US
dc.typeArticleen_US

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