Pinealectomy increases oxidant damage in kidney and testis caused by hyperthyroidism in rats

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dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorAydin, Leyla
dc.contributor.authorOztekin, Esma
dc.contributor.authorTuncer, Isik
dc.date.accessioned2020-03-26T17:04:01Z
dc.date.available2020-03-26T17:04:01Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThyroid hormones regulate energy metabolism and act on mitochondria which are an important source of free radicals in the cell. The pineal gland activates antioxidant systems via melatonin secretion and thus has a protective function in body tissues. The present study was conducted to determine the oxidative damage caused by hyperthyroidism in kidney and testis tissues of pinealectomized rats. Experimental animals were allocated to three groups: 1, control group; 2, sham pinealectomy-hyperthyroidic group; and 3, pinealectomy-hyperthyroidic group. Hyperthyroidism was induced by A 3-week intraperitoneal administration of thyroxin after sham pinealectomy or pinealectomy. Malondialdehyde (MDA) and glutathione (GSH) levels were determined in kidney and testis tissues. MDA levels of the kidney and testis tissue in the pinealectomy and hyperthyroidic groups were significantly higher than those in the sham pinealectomy-hyper-thyroidic group and the control group (p < 0.001). GSH levels of both kidney and testis tissues were significantly higher in the sham-pinealectomy-hyperthyroidic group when compared to the other two groups (p < 0.001). This increase in GSH levels was more evident in the pinealectomy-hyperthyroidic group than in the control group (p < 0.001). The results of our study demonstrate that MDA and GSH levels in kidney and testis tissues increased due to hyperthyroidism and that pinealectomy made the increase in MDA levels more apparent, while decreasing GSH levels. Copyright (c) 2005 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1254en_US
dc.identifier.endpage453en_US
dc.identifier.issn0263-6484en_US
dc.identifier.issn1099-0844en_US
dc.identifier.issue5en_US
dc.identifier.pmid16142690en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage449en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.1254
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20612
dc.identifier.volume24en_US
dc.identifier.wosWOS:000240575300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCELL BIOCHEMISTRY AND FUNCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjectpinealectomyen_US
dc.subjectkidneyen_US
dc.subjecttestisen_US
dc.subjectraten_US
dc.titlePinealectomy increases oxidant damage in kidney and testis caused by hyperthyroidism in ratsen_US
dc.typeArticleen_US

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