The relation between Ring Box-1 protein overexpression and tumor grade and stage in bladder urothelial cell carcinoma

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dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorKaynar, Mehmet
dc.contributor.authorKarabagli, Pinar
dc.contributor.authorGergerlioglu, Nursadan
dc.contributor.authorGoktas, Serdar
dc.date.accessioned2020-03-26T19:43:07Z
dc.date.available2020-03-26T19:43:07Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Ring Box Protein-1 (RBX-1), a component of SCF E3 ubiquitin ligases, has a crucial role in bladder urothelial cell carcinoma (UCC) carcinogenesis and progression. OBJECTIVES: In the present study, it is aimed to determine the expression of RBX-1 protein in bladder UCC and the association between tumor grade, stage and RBX-1 expression. METHODS: Ninety UCC samples and 20 samples containing foci of normal bladder urothelium were recruited and analyzed immunohistochemically in terms of RBX-1 expression. Immuno-reactivity scoring system (IRS) was used to determine RBX-1 expression levels. RESULTS: RBX-1 overexpression was associated with high tumor grade (p = 0.001) and advanced stage (p = 0.001). pT1 tumors showed higher RBX-1 expression than pTa tumors. pT2 tumors showed not only higher expression than pTa tumors but also higher expression than the total of pTa and pT1 groups combined. There was no statistically significant relation between RBX-1 expression and patient gender (p = 0.116) or age (p = 0.191). CONCLUSIONS: In bladder UCC, RBX-1 overexpression is associated with high tumor grade and advanced stage and represents biological potential of invasiveness and aggressive disease. Results of the present study have to be supported with further studies to reveal clinical and therapeutic implications of RBX-1 overexpression in bladder UCC.en_US
dc.description.sponsorshipSelcuk University Scientific Investigations Projects Coordinatorship [14401053]en_US
dc.description.sponsorshipThe authors thank Dr. Tahir Kemal Sahin for statistical evaluation of the study, and Dr. Enver Ahmet Demir and Dr. H. Serdar Gergerlioglu for their help in preparing graphs. This study was supported by grants from Selcuk University Scientific Investigations Projects Coordinatorship with the project number 14401053.en_US
dc.identifier.doi10.3233/CBM-170002en_US
dc.identifier.endpage394en_US
dc.identifier.issn1574-0153en_US
dc.identifier.issn1875-8592en_US
dc.identifier.issue4en_US
dc.identifier.pmid28946546en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://dx.doi.org/10.3233/CBM-170002
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35603
dc.identifier.volume20en_US
dc.identifier.wosWOS:000418069400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIOS PRESSen_US
dc.relation.ispartofCANCER BIOMARKERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectUrothelial cell carcinomaen_US
dc.subjectprognosisen_US
dc.subjectinvasivenessen_US
dc.subjectRing Box-1en_US
dc.subjectimmunohistochemistryen_US
dc.titleThe relation between Ring Box-1 protein overexpression and tumor grade and stage in bladder urothelial cell carcinomaen_US
dc.typeArticleen_US

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