Effect of Three Centaurea Species Collected from Central Anatolia Region of Turkey on Human Melanoma Cells

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dc.contributor.authorRusso, Alessandra
dc.contributor.authorCardile, Venera
dc.contributor.authorGraziano, Adriana C. E.
dc.contributor.authorRigano, Daniela
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSenatore, Felice
dc.date.accessioned2020-03-26T19:23:45Z
dc.date.available2020-03-26T19:23:45Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCentaurea is the largest genus within the Asteraceae family. Many members of this genus are used in traditional folk medicine, such as Centaurea pulchella used to treat skin problems such as to resolve the abscess. Although biological activities of many Centaurea species have been investigated in different countries and Turkey, cytotoxic effect of C. patula, C. pulchella and C. tchihatcheffii has not been studied yet. Melanoma is one of the most invasive and deadly forms of skin cancer. Therefore, in an ongoing effort to identify new natural anticancer products for the treatment and/or prevention of melanoma cancer, the present study was undertaken to investigate the effect of these Centaurea species, collected from Central Anatolia region of Turkey on cell growth and death in human melanoma cell line, A375. The results revealed that all extracts were able to inhibit, after 48 h of treatment, the growth of cancer cells, that could be related to an overall action of the phenolic compounds present. In fact, C. pulchella, with the highest level of phenolics, showed a major activity followed by C. patula and C. tchihatcheffii. Our data also demonstrate that these natural products induce apoptotic cell death. In conclusion, the study of plant extracts for their cytotoxic and apoptotic properties has shown that medicinal herbs from Centaurea species might have also importance in the prevention and treatment of melanoma.en_US
dc.identifier.endpage278en_US
dc.identifier.issn1934-578Xen_US
dc.identifier.issn1555-9475en_US
dc.identifier.issue3en_US
dc.identifier.pmid27169173en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33489
dc.identifier.volume11en_US
dc.identifier.wosWOS:000372690300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURAL PRODUCTS INCen_US
dc.relation.ispartofNATURAL PRODUCT COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCentaurea speciesen_US
dc.subjectPhenolic compoundsen_US
dc.subjectMelanomaen_US
dc.subjectCell growthen_US
dc.subjectApoptosisen_US
dc.subjectNecrosisen_US
dc.titleEffect of Three Centaurea Species Collected from Central Anatolia Region of Turkey on Human Melanoma Cellsen_US
dc.typeArticleen_US

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