Therapeutic management of neonatal hemochromatosis: Report of four cases and literature review

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dc.contributor.authorAnnagür, Ali
dc.contributor.authorAltunhan, Hüseyin
dc.contributor.authorYüksekkaya, Hasan Ali
dc.contributor.authorÖrs, Rahmi
dc.date.accessioned2020-03-26T18:17:18Z
dc.date.available2020-03-26T18:17:18Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNeonatal hemochromatosis (NH) is a rare disease of iron metabolism that starts at intrauterine period causing liver failure and extrahepatic siderozis. The etiology of NH has not been understood exactly, yet it is accepted that a maternofetal alloimmune disorder that leads to liver failure in fetus causes the illness. The prognosis of NH is generally bad and death is inevitable if left untreated. The efficiency of chelation antioxidant coctail used in medical treatment is between 10% and 20% and these patients frequently need liver transplantation. In our study, we presented four newborn cases diagnosed as NH and treated medically. Of the four patients, one died of pulmonary hemorrhage and another died of multiorgan failure in the first week of hospitalization. The other two patients' clinical status and laboratory parameters recovered with medical treatment. However, since liver transplantation was not carried out, one of these patients died at the age of two and a half months and the other at eighth month due to sepsis. In this study, we would like to emphasize the importance of early liver transplantation in patients recovered with medical treatment.en_US
dc.identifier.doi10.1177/0960327110396534en_US
dc.identifier.endpage1734en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue10en_US
dc.identifier.pmid21247995en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1728en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327110396534
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27009
dc.identifier.volume30en_US
dc.identifier.wosWOS:000295812200037en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectneonatal hemochromatosisen_US
dc.subjectneonatal iron storage diseaseen_US
dc.subjectacute liver failureen_US
dc.subjectalloimmune diseaseen_US
dc.subjectliver transplantationen_US
dc.subjectneonateen_US
dc.titleTherapeutic management of neonatal hemochromatosis: Report of four cases and literature reviewen_US
dc.typeReviewen_US

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