Assessment of ocular neurotoxicity in patients treated with systemic cancer chemotherapeutics

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dc.contributor.authorBakbak B.
dc.contributor.authorGedik S.
dc.contributor.authorKoktekir B.E.
dc.contributor.authorYavuzer K.
dc.contributor.authorTulek B.
dc.contributor.authorKanat F.
dc.contributor.authorPancar E.
dc.date.accessioned2020-03-26T18:59:00Z
dc.date.available2020-03-26T18:59:00Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: Cisplatin and Paclitaxel are two chemotherapeutic agents known to produce neurotoxicity when used for cumulative dose regimens. In this study we aim to assess their toxicity in the optic nerve, and to evaluate the retinal nerve fibre layer (RNFL) thickness and visual field changes in lung cancer patients treated with Cisplatin and Paclitaxel. Methods: Fifteen patients who were treated intravenously with 75mg/m2 cisplatin and 175mg/m 2 paclitaxel every 3 weeks, up to a maximum of six courses, were enrolled in this prospective clinical trial. All patients underwent complete ophthalmological assessments before their treatments began, as well as three months after the completion of their treatments. The RNFL thickness measurements were performed using optical coherence tomography (OCT). Functional testing included the use of frequency-doubling technology (FDT) perimetry and the Humphrey visual field analyser (HFA). The main outcome measurements included the average RNFL thicknesses and visual field indices (mean deviation [MD] and pattern standard deviation [PSD]). Results: The median age of the 15 patients (nine male and six female) was 63.49 years old (range: 53-77). The average RNFL thickness measurement during the baseline examination was 103.73?m (range: 97-111). Three months after the cessation of treatment the RNFL thickness declined to 97.4?m (range: 91-102). Statistical analysis showed a significant thinning between the two measurements (p=0.032). The MD and PSD values recorded by the HFA demonstrated no statistically significant changes 3 months after the cessation of treatment (p>0.207 and p>0.186, respectively). There were statistically significant decreases in both the MD (0.48 to-1.13dB) and PSD (2.13 to 0.65dB) indices measured by the FDT perimetry (p=0.041 and p=0.025, respectively). Conclusions: In our study, the systemic administration of Cisplatin and Paclitaxel affected the peripapillary RNFL thicknesses and visual field indices as revealed by FDT perimetry. OCT and FDT perimetry may be adjunctive tools for the screening of ocular toxicity in patients treated with these agents. © 2014 Informa Healthcare USA, Inc.en_US
dc.identifier.doi10.3109/15569527.2013.787087en_US
dc.identifier.endpage10en_US
dc.identifier.issn1556-9527en_US
dc.identifier.issue1en_US
dc.identifier.pmid23638802en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://dx.doi.org/10.3109/15569527.2013.787087
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31373
dc.identifier.volume33en_US
dc.identifier.wosWOS:000331847200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCisplatinen_US
dc.subjectFrequency-doubling technologyen_US
dc.subjectOcular toxicityen_US
dc.subjectPaclitaxelen_US
dc.subjectRetinal nerve fibre layeren_US
dc.titleAssessment of ocular neurotoxicity in patients treated with systemic cancer chemotherapeuticsen_US
dc.typeArticleen_US

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