THE EFFECT OF ILOPROST ON RENAL DYSFUNCTION AFTER RENAL I/R USING CYSTATIN C AND beta(2)-MICROGLOBULIN MONITORING

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dc.contributor.authorSahsivar, M. Orkun
dc.contributor.authorNarin, Cueneyt
dc.contributor.authorKiyici, Aysel
dc.contributor.authorToy, Hatice
dc.contributor.authorEge, Erdal
dc.contributor.authorSarigul, Ali
dc.date.accessioned2020-03-26T17:40:34Z
dc.date.available2020-03-26T17:40:34Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the effect of iloprost, a cytoprotective prostacyclin analog, on renal injury during unilateral renal I/R in rats and to determine whether the levels of serum cystatin C (CyC) and beta(2)-microglobulin (B2M), as markers of glomerular function, might denote this injury. Thirty-two Wistar rats were randomized into four groups (n = 8) as follows: control (sham laparotomy), renal I/R (60-min left renal ischemia and 120-min reperfusion), renal I/R + iloprost (20 ng kg(-1) min(-1) infusion during renal I/R period, i.v.), and control + iloprost. Blood and kidney tissue samples were obtained for biochemical and histological analysis from all rats. Serum urea, creatinine, CyC, and B2M levels were evaluated for biochemical analysis. Histopathological changes in renal structure were examined for histological analysis. Serum urea, creatinine, and CyC levels were significantly increased in the renal I/R group. Iloprost treatment decreased these three markers in the renal I/R + iloprost group. beta(2)-Microglobulin levels were not significantly changed in any group. Histological analyses showed that renal I/R elicited significant renal injury, whereas iloprost significantly decreased I/R-induced renal injury. Serum CyC level is one of the good indicators of acute renal damage due to I/R produced by renal artery occlusion. In contrast, we have shown that there are no significant changes in the levels of serum B2M levels that would make it an accurate diagnostic tool for detecting acute changes in renal injury subject to renal I/R in rats.en_US
dc.identifier.doi10.1097/SHK.0b013e3181a1ba54en_US
dc.identifier.endpage502en_US
dc.identifier.issn1073-2322en_US
dc.identifier.issn1540-0514en_US
dc.identifier.issue5en_US
dc.identifier.pmid19295492en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://dx.doi.org/10.1097/SHK.0b013e3181a1ba54
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23925
dc.identifier.volume32en_US
dc.identifier.wosWOS:000271409700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofSHOCKen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute renal failureen_US
dc.subjectbeta(2)-microglobulinen_US
dc.subjectcystatin Cen_US
dc.subjectiloprosten_US
dc.subjectI/Ren_US
dc.titleTHE EFFECT OF ILOPROST ON RENAL DYSFUNCTION AFTER RENAL I/R USING CYSTATIN C AND beta(2)-MICROGLOBULIN MONITORINGen_US
dc.typeArticleen_US

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