Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism

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dc.contributor.authorMogulkoc, R
dc.contributor.authorBaltaci, AK
dc.contributor.authorOztekin, E
dc.contributor.authorAydin, L
dc.contributor.authorSivrikaya, A
dc.date.accessioned2020-03-26T17:03:53Z
dc.date.available2020-03-26T17:03:53Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractImpairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism+melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues. MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism+melatonin supplemented groups (p < 0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p < 0.001). These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.lfs.2006.01.009en_US
dc.identifier.endpage315en_US
dc.identifier.issn0024-3205en_US
dc.identifier.issue3en_US
dc.identifier.pmid16464477en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.lfs.2006.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20578
dc.identifier.volume79en_US
dc.identifier.wosWOS:000238301400015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofLIFE SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjectmelatonin administrationen_US
dc.subjectoxidant damageen_US
dc.subjectraten_US
dc.titleMelatonin prevents oxidant damage in various tissues of rats with hyperthyroidismen_US
dc.typeArticleen_US

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