Mean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney disease

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dc.contributor.authorSolak, Yalcin
dc.contributor.authorYilmaz, Mahmut Ilker
dc.contributor.authorSaglam, Mutlu
dc.contributor.authorDemirbas, Seref
dc.contributor.authorVerim, Samet
dc.contributor.authorUnal, Hilmi Umut
dc.contributor.authorGaipov, Abduzhappar
dc.date.accessioned2020-03-26T18:42:26Z
dc.date.available2020-03-26T18:42:26Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAimMean corpuscular volume (MCV) is a measure of size of red blood cells. Recently a few studies showed an association of macrocytosis with all-cause mortality. We aimed to assess the relationship of MCV with cardiovascular (CV) morbidity and mortality in patients with chronic kidney disease (CKD), and the effect of MCV on endothelial function. MethodsThis is an observational cohort study with a prospectively maintained cohort of patients with stage 1-5 CKD. Estimated glomerular filtration rate (eGFR), flow mediated dilatation (FMD) and laboratory values were measured at baseline. Multivariate linear and Cox regression analyses were used to predict independent associations of FMD and composite CV events, respectively. ResultsA total of 309 patients were included in the study. In contrast to anaemia MCV did not show a significant change among CKD groups. MCV was an independent predictor of FMD in addition to serum haemoglobin, CRP, diabetes, systolic blood pressure (SBP) and eGFR. Median MCV value was 85fl. Kaplan-Meier analysis showed that at 38 months the survival rate was 97.6% in the group with MCV < 85 compared to 81.6% in the arm with MCV 85 (P<0.001, log-rank test). Cox regression analysis showed MCV as a predictor of composite CV events independent of major confounding factors. ConclusionThis is the first study in the literature showing an independent association of MCV and FMD. Our results also determined MCV as an independent predictor of composite CV events independent of anaemia, inflammation, diabetes and eGFR in patients with CKD.en_US
dc.description.sponsorshipERA-EDTAen_US
dc.description.sponsorshipThe authors would like to express their sincere appreciation to FAVOR (FMF Arthritis Vasculitis and Orphan Diseases Research/http://www.favor.org.tr) web registries at Gulhane Military Medical Academy, Institute of Health Sciences for their support in epidemiological and statistical advisory and invaluable guidance for the preparation of the manuscript. Dr. A. G. supported by Fellowship award from ERA-EDTA.en_US
dc.identifier.doi10.1111/nep.12130en_US
dc.identifier.endpage735en_US
dc.identifier.issn1320-5358en_US
dc.identifier.issn1440-1797en_US
dc.identifier.issue11en_US
dc.identifier.pmid23848392en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage728en_US
dc.identifier.urihttps://dx.doi.org/10.1111/nep.12130
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29632
dc.identifier.volume18en_US
dc.identifier.wosWOS:000326244300006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofNEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcardiovascular eventen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectflow mediated dilatationen_US
dc.subjectmean corpuscular volumeen_US
dc.subjectpredictionen_US
dc.titleMean corpuscular volume is associated with endothelial dysfunction and predicts composite cardiovascular events in patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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