Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats
Yükleniyor...
Dosyalar
Tarih
2020 Eylül
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, it is aimed to determine the possible effects of curcumin on hematological parameters in aflatoxin applied
rats. Thirty eight healthy male Wistar Albino rats were used in the study. Group I animals was no applied. Animals in Group II
were orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in
10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for
60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin
dissolved in 10% DMSO daily for 60 days. At the end of the study, erythrocyte count, leukocyte count, platelet count,
hemoglobin amount, hematocrit value, percentage ratios of leukocyte types, mean corpuscular volume (MCV), mean
corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined in blood samples
taken from all animals. In the study, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC level in the
aflatoxin applied rats significantly decreased compared to the control group (p<0.05). MCV level in the aflatoxin applied rats
was found significantly higher compared to the control group (p<0.05). In the group in which aflatoxin and curcumin were
administered together, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC levels were found to be
significantly higher compared to the group administered only aflatoxin (p<0.05). In the study, the leukocyte count significantly
decreased in the aflatoxin group compared to the control group (p<0.05). Granulocyte and monocyte percentage significantly
increased depend on aflatoxin application (p<0.05). In the group in which aflatoxin and curcumin were administered together,
the leukocyte count significantly increased compared to the aflatoxin group (p<0.05). We concluded that curcumin may
alleviate the abnormalities in hematological parameters resulting from aflatoxicosis.
Açıklama
Anahtar Kelimeler
Aflatoxin, Curcumin, Hematological Parameters, Rats
Kaynak
Turkish Journal of Sport and Exercise
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
2
Künye
Uluışık, D., Keskin, E., Hatipoğlu, D., (2020). Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats. Turkish Journal of Sport and Exercise, 22(2), 265-270.
DOI: 10.15314/tsed.735620
