Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats

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dc.authorid0000-0003-1462-0836en_US
dc.authorid0000-0003-3839-0414en_US
dc.authorid0000-0003-3790-7821en_US
dc.contributor.authorUluışık, Deniz
dc.contributor.authorKeskin, Ercan
dc.contributor.authorHatipoğlu, Durmuş
dc.date.accessioned2023-08-26T13:11:58Z
dc.date.available2023-08-26T13:11:58Z
dc.date.issued2020 Eylülen_US
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractIn this study, it is aimed to determine the possible effects of curcumin on hematological parameters in aflatoxin applied rats. Thirty eight healthy male Wistar Albino rats were used in the study. Group I animals was no applied. Animals in Group II were orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. At the end of the study, erythrocyte count, leukocyte count, platelet count, hemoglobin amount, hematocrit value, percentage ratios of leukocyte types, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined in blood samples taken from all animals. In the study, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC level in the aflatoxin applied rats significantly decreased compared to the control group (p<0.05). MCV level in the aflatoxin applied rats was found significantly higher compared to the control group (p<0.05). In the group in which aflatoxin and curcumin were administered together, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC levels were found to be significantly higher compared to the group administered only aflatoxin (p<0.05). In the study, the leukocyte count significantly decreased in the aflatoxin group compared to the control group (p<0.05). Granulocyte and monocyte percentage significantly increased depend on aflatoxin application (p<0.05). In the group in which aflatoxin and curcumin were administered together, the leukocyte count significantly increased compared to the aflatoxin group (p<0.05). We concluded that curcumin may alleviate the abnormalities in hematological parameters resulting from aflatoxicosis.en_US
dc.identifier.citationUluışık, D., Keskin, E., Hatipoğlu, D., (2020). Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats. Turkish Journal of Sport and Exercise, 22(2), 265-270. DOI: 10.15314/tsed.735620en_US
dc.identifier.doi10.15314/tsed.735620en_US
dc.identifier.endpage270en_US
dc.identifier.issn2147-5652
dc.identifier.issue2en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/49931
dc.identifier.volume22en_US
dc.institutionauthorUluışık, Deniz
dc.institutionauthorKeskin, Ercan
dc.institutionauthorHatipoğlu, Durmuş
dc.language.isoenen_US
dc.publisherSelçuk Üniversitesien_US
dc.relation.ispartofTurkish Journal of Sport and Exerciseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAflatoxinen_US
dc.subjectCurcuminen_US
dc.subjectHematological Parametersen_US
dc.subjectRatsen_US
dc.titleEffects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Ratsen_US
dc.typeArticleen_US

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