The effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity of rat bone marrow cells

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dc.contributor.authorYener, Yesim
dc.contributor.authorDikmenli, Musa
dc.date.accessioned2020-03-26T18:16:47Z
dc.date.available2020-03-26T18:16:47Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: Although the pathophysiological importance of emperipolesis is not known exactly, it has been reported to increase significantly in cases of various cancer types, different tumours and thrombosis disorders. In this study the effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity in rat bone marrow cells were determined. For this purpose, two separate experiments were performed with Sprague-Dawley rats gavaged with 0, 30, 45 and 60 mg acrylamide kg(-1) body weight (BW) for five consecutive days. In the second experiment, 3 mg colchicine kg(-1) BW was injected intraperitoneally 2 h before cervical dislocation. Bone marrow samples were taken 24 h after the last application in both experiments. RESULTS: It was found that only the highest dose of acrylamide significantly decreased the incidence of megakaryocytic emperipolesis and that the types of bone marrow cells engulfed by megakaryocytes were mostly neutrophil granulocytes. Neither megakaryocytes nor engulfed cells showed any morphological degeneration. In the mitotic activity experiment, doses of 45 and 60 mg acrylamide kg(-1) BW decreased the mitotic activity of bone marrow cells in comparison with the control group. CONCLUSION: It was concluded that the decrease in megakaryocytic emperipolesis frequency might be a consequence of the decrease in mitotic activity in bone marrow cells. (C) 2011 Society of Chemical Industryen_US
dc.description.sponsorship(BAP) Coordinating Office of Selcuk UniversitySelcuk University [06101002]en_US
dc.description.sponsorshipWe express our thanks to the Scientific Research Projects (BAP) Coordinating Office of Selcuk University (project 06101002) for financial support.en_US
dc.identifier.doi10.1002/jsfa.4388en_US
dc.identifier.endpage1813en_US
dc.identifier.issn0022-5142en_US
dc.identifier.issn1097-0010en_US
dc.identifier.issue10en_US
dc.identifier.pmid21452172en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1810en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jsfa.4388
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26926
dc.identifier.volume91en_US
dc.identifier.wosWOS:000291879600013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF THE SCIENCE OF FOOD AND AGRICULTUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacrylamideen_US
dc.subjectmegakaryocytic emperipolesisen_US
dc.subjectmitotic activityen_US
dc.subjectbone marrowen_US
dc.titleThe effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity of rat bone marrow cellsen_US
dc.typeArticleen_US

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