Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester

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dc.contributor.authorOzdemir, Suna
dc.contributor.authorKiyici, Aysel
dc.contributor.authorBalci, Osman
dc.contributor.authorGoktepe, Halime
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T18:13:49Z
dc.date.available2020-03-26T18:13:49Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage. This study was undertaken to evaluate IMA levels in women with recurrent pregnancy loss (RPL). Study design: This case-control study was performed between March 2008 and September 2009, at the Department of Obstetrics and Gynecology of Meram School of Medicine. Serum IMA and albumin concentrations were assessed in 43 women with a history of two or more unexplained first trimester miscarriages (group 1), and 42 healthy pregnant women (group 2) in the first trimester. IMA, adjusted IMA and albumin concentrations were compared between the groups. Statistical analysis was performed using Student's t-test and Mann-Whitney U test. Results: IMA and adjusted IMA levels were significantly higher in women with RPL (1.11 + 0.08 and 1.09 + 0.09, respectively) compared to women in group 2 (0.88 + 0.10 and 0.88 + 0.11, respectively). Albumin levels in group 1 were significantly lower compared with group 2. There was a negative correlation between IMAand albumin levels in each group. Conclusion: Maternal IMA levels appear to be elevated in women with early RPL This finding may suggest that an abnormally high hypoxic intrauterine environment may be associated with abnormal placental development that contributes to early miscarriage. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2010.12.004en_US
dc.identifier.endpage212en_US
dc.identifier.issn0301-2115en_US
dc.identifier.issn1872-7654en_US
dc.identifier.issue2en_US
dc.identifier.pmid21185113en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejogrb.2010.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26167
dc.identifier.volume155en_US
dc.identifier.wosWOS:000289454600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectRecurrent pregnancy lossen_US
dc.subjectAbnormal placentaen_US
dc.titleAssessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimesteren_US
dc.typeArticleen_US

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