AN EARLY DIAGNOSTIC TOOL FOR DIABETIC NEUROPATHY: CONDUCTION VELOCITY DISTRIBUTION

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dc.contributor.authorTuncer, Seckin
dc.contributor.authorDalkilic, Nizamettin
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2020-03-26T18:13:43Z
dc.date.available2020-03-26T18:13:43Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDiabetes is a metabolic disorder that. affects much of the human population. As a secondary complication, diabetic neuropathy causes time-dependent damage to peripheral nerves. In this study, experimental diabetes was induced by streptozotocin (STZ; 50 mg/kg intraperitoneally) in rats. Diabetic animals were grouped into those with 2 or 4 weeks of diabetes, whereas a control group received only the STZ vehicle (0.1 M citrate). Sciatic nerves were dissected, and compound action potentials (CAPS) were recorded. Results deduced by conventional calculation carried less information when compared with conduction velocity distribution (CVD) obtained by a computer-based mathematical model. Using the conventional approach, statistically significant changes were first seen in the fourth week of diabetes, whereas results deduced by CVD measurement could be seen in the second week. Consequently, the CVD calculation provides more information for the early diagnosis of neuropathies compared with classical conduction velocity measurements. Muscle Nerve 43: 237-244, 2011en_US
dc.description.sponsorshipScientific Research and Project Coordination Center of Selcuk University, Meram, Konya, TurkeySelcuk University [BAP 07202012]en_US
dc.description.sponsorshipThis study was presented at the 20th National Biophysics Congress, Mersin, Turkey, and at the 9th International Congress of ale Polish Neuroscience Society, Warsaw, Poland. This research was partially supported by the Scientific Research and Project Coordination Center of Selcuk University (Fund No. BAP 07202012), Meram, Konya, Turkey, and includes part of S.T.'s master's of science thesis.en_US
dc.identifier.doi10.1002/mus.21837en_US
dc.identifier.endpage244en_US
dc.identifier.issn0148-639Xen_US
dc.identifier.issn1097-4598en_US
dc.identifier.issue2en_US
dc.identifier.pmid21254089en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://dx.doi.org/10.1002/mus.21837
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26106
dc.identifier.volume43en_US
dc.identifier.wosWOS:000286558300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofMUSCLE & NERVEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcompound action potentialen_US
dc.subjectdiabetic peripheral neuropathyen_US
dc.subjectnerve conduction velocity distributionen_US
dc.subjectraten_US
dc.subjectsciatic nerveen_US
dc.titleAN EARLY DIAGNOSTIC TOOL FOR DIABETIC NEUROPATHY: CONDUCTION VELOCITY DISTRIBUTIONen_US
dc.typeArticleen_US

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