Evaluation of aneuploidy frequency for chromosomes 6 and 17 in eyelid tumours using the FISH technique

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dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorAcar, Hasan
dc.contributor.authorZengin, Nazmi
dc.contributor.authorOkudan, Suleyman
dc.date.accessioned2020-03-26T17:17:25Z
dc.date.available2020-03-26T17:17:25Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAlthough basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are very common skin tumours, the incidence of chromosome aneuploidy with regard to the eyelid has not been investigated. We aimed to find the frequency of chromosome 6 and 17 aneuploidies in eyelid tumours' interphase nuclei with fluorescence in situ hybridization (I-FISH) with chromosome specific DNA probes. I-FISH with chromosome 6 and 17 centromere specific DNA probes was used in the eyelids of 10 patients with BCC or SCC and the peripheral blood cells of 10 healthy donors as controls. The frequency of chromosome 6 and 17 aneuploidies was significantly higher in 7 out of 10 patients and 5 out of 10 patients, respectively, than in controls, indicating a higher frequency of aneuploidy in BCC than in SCC of the eyelid. Distribution of hybridization signals for chromosome 6 and 17 was wide ranging, indicating heterogeneity of cell populations with aneuploidy between patients. These findings indicate that acquisition of chromosome aneuploidies in eyelid tumours may have an important pathogenic role in both BCC and SCC of the eyelid area. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cellbi.2006.10.003en_US
dc.identifier.endpage219en_US
dc.identifier.issn1065-6995en_US
dc.identifier.issn1095-8355en_US
dc.identifier.issue3en_US
dc.identifier.pmid17164085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.cellbi.2006.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21387
dc.identifier.volume31en_US
dc.identifier.wosWOS:000244787800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCELL BIOLOGY INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbasal cell carcinomaen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectchoromosome 6en_US
dc.subjectchoromosome 17en_US
dc.subjectFISHen_US
dc.subjectinterphase nucleien_US
dc.subjecteyeliden_US
dc.titleEvaluation of aneuploidy frequency for chromosomes 6 and 17 in eyelid tumours using the FISH techniqueen_US
dc.typeArticleen_US

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