Impaired thiol-disulfide balance in acute brucellosis

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dc.contributor.authorKölgelier, Servet
dc.contributor.authorErgin, Merve
dc.contributor.authorDemir, Lütfi Saltuk
dc.contributor.authorİnkaya, Ahmet Cağkan
dc.contributor.authorDemir, Nazlım Aktuğ
dc.contributor.authorAlışık, Murat
dc.contributor.authorErel, Özcan
dc.date.accessioned2020-03-26T19:43:49Z
dc.date.available2020-03-26T19:43:49Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe objective of this study was to examine a novel profile: thiol-disulfide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulfide profile tests were analyzed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 ± 48.20 µmol/L in the acute brucellosis group and 461.13 ± 45.37 µmol/L in the healthy group, and total thiol levels were 298.58 ± 51.78 µmol/L in the acute brucellosis group and 504.83 ± 51.05 µmol/L in the healthy group (p < 0.001, for both). The disulfide/na-tive thiol ratios and disulfide/total thiol ratios were significantly higher, and native thiol/total thiol ratios were significantly lower in patients with acute brucellosis than in the healthy controls (p < 0.001, for all ratios). There were either positive or negative relationships between ceruloplasmin levels and thiol-disulfide parameters. The thiol-disulfide homeostasis was impaired in acute brucellosis. The strong associations between thiol-disulfide parameters and a positive acute-phase reactant reflected the disruption of the balance between the antioxidant and oxidant systems. Since thiol groups act as anti-inflammatory mediators, the alteration in the thiol-disulfide homeostasis may be involved in brucellosis. © 2017, National Institute of Health. All rights reserved.en_US
dc.identifier.citationKolgelier, S., Ergin, M., Demir, L. S., Inkaya, A. C., Demir, N. A., Alisik, M., Erel, O. (2017). Impaired Thiol-Disulfide Balance İn Acute Brucellosis. Japanese Journal of Infectious Diseases, 70(3), 258-262.
dc.identifier.doi10.7883/yoken.JJID.2016.196en_US
dc.identifier.endpage262en_US
dc.identifier.issn1344-6304en_US
dc.identifier.issue3en_US
dc.identifier.pmid27795469en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://dx.doi.org/10.7883/yoken.JJID.2016.196
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35761
dc.identifier.volume70en_US
dc.identifier.wosWOS:000402693200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemir, Nazlim Aktug.
dc.language.isoenen_US
dc.publisherNational Institute of Healthen_US
dc.relation.ispartofJapanese Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleImpaired thiol-disulfide balance in acute brucellosisen_US
dc.typeArticleen_US

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