Glutathione S-transferase M1 and T1 genotypes and myocardial infarction

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dc.contributor.authorCora, Tulin
dc.contributor.authorTokac, Mehmet
dc.contributor.authorAcar, Hasan
dc.contributor.authorSoylu, Ahmet
dc.contributor.authorInan, Ziya
dc.date.accessioned2020-03-26T18:42:05Z
dc.date.available2020-03-26T18:42:05Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMyocardial infarction (MI), which is the most important manifestation of coronary artery disease, is the leading cause of morbidity and mortality in the world. Glutathione S transferases (GSTs) are enzymes responsible for the metabolism of numerous xenobiotics and are known to be polymorphic in humans. We investigated the association between the GSTM1 and GSTT1 gene polymorphisms and MI. The study consists of 296 healthy controls and 324 consecutive patients who had undergone coronary angiography for suspicion of coronary artery disease and with a past history of myocardial infarction. DNA was extracted from whole blood of patient and control. GSTM1 and GSTT1 gene polymorphisms were examined using multiplex PCR. We found that the null GSTM1 was associated with protective effect on MI, although this increase was not significant for GSTM1 (p < 0.054). However, GSTT1 genotype was associated with an increase in the risk of developing MI. In addition to after adjusting other all coronary risk factors, the interactive effect of GSTT1 null genotype remained statistically significant (p < 0.001) for MI disease but GSTM1 null genotype was not statistically significant. Patients, who smoke having the null genotypes of GSTM1, were at a higher risk for developing MI (p < 0.001, OR = 0.41, 95 % CI = 0.240-0.207). There was an effect of interaction of GSTM1 null genotype and smoking on MI development between patient and control groups (p < 0.001). Our results showed that individuals with the null genotypes for GSTM1 had protective effect, while GSTT1 was at a higher risk for MI disease. In addition, there was additional effects of smoking when smoking and non-smoking groups were compared.en_US
dc.description.sponsorshipSelcuk University Research FoundationSelcuk Universityen_US
dc.description.sponsorshipWe thank Dr. Coskun Kus and Aysel Kalayci for statistical analysis, Feyza Ekizer, Aundreta Farris for editing English. Funding: The work was supported by Selcuk University Research Foundation.en_US
dc.identifier.doi10.1007/s11033-012-2401-6en_US
dc.identifier.endpage3267en_US
dc.identifier.issn0301-4851en_US
dc.identifier.issn1573-4978en_US
dc.identifier.issue4en_US
dc.identifier.pmid23275234en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3263en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11033-012-2401-6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29546
dc.identifier.volume40en_US
dc.identifier.wosWOS:000316221100055en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofMOLECULAR BIOLOGY REPORTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlutathione S-transferaseen_US
dc.subjectGenotypeen_US
dc.subjectPolymorphismen_US
dc.subjectMyocardial Infarctionen_US
dc.titleGlutathione S-transferase M1 and T1 genotypes and myocardial infarctionen_US
dc.typeArticleen_US

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