Erythromycin Inhibits Prostaglandin F-2 Alpha-İnduced Contractions of Myometrium Isolated From Non-Pregnant Rats

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dc.contributor.authorÇelik, Hüsnü
dc.contributor.authorAyar, Ahmet
dc.contributor.authorBaltacı, Abdülkerim
dc.contributor.authorTuğ, Niyazi
dc.date.accessioned2020-03-26T16:39:03Z
dc.date.available2020-03-26T16:39:03Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective The aim of this study was to investigate the effects of erythromycin on prostaglandin F-2alpha (PGF(2alpha))-induced contractions of isolated myometrial strips from non-pregnant rats. Design In vitro pharmacological study. Setting Firat University Faculty of Medicine. Sample Myometrium samples were taken from 55 adult Wistar rats. Methods Myometrial strips were isolated from mature, non-pregnant Wistar rats. Isometric contractions of these strips were induced with 1 muM PGF(2alpha). Effects of 0.01, 0.1, 0.2, 0.5 and 1 mM erythromycin on the frequency and amplitude of these PGF(2alpha)-induced contractions were recorded. Main outcome measures The inhibition of prostaglandin F-2alpha-induced contractions in vitro. Results Application of 0.01 mM erythromycin had no effect on either amplitude or frequency of contractions. However, 0.1, 0.2, 0.5 and 1 mM erythromycin decreased the frequency and amplitude of PGF(2alpha)-induced contractions. The inhibitory effect of erythromycin on amplitude was 27%, 38%, 54% and 83% (P < 0.05), and that on frequency was 10%, 16%, 32% and 61% (P < 0.05) at 0.1, 0.2, 0.5 and 1 mM concentrations, respectively. Conclusion The results of this study demonstrate that erythromycin inhibits PGF(2alpha)-induced contractions in rat myometrium. Because PGF(2alpha)-induced contractions have been suggested to be involved in the pathogenesis of primary dysmenorrhoea, effects of erythromycin in this clinical entity may present a new approach for the treatment.en_US
dc.identifier.citationÇelik, H., Ayar, A., Baltacı, A., Tuğ, N., (2002). Erythromycin Inhibits Prostaglandin F-2 Alpha-İnduced Contractions of Myometrium Isolated From Non-Pregnant Rats. Bjog-an International Journal of Obstetrics and Gynaecology, (109), 1036-1040.
dc.identifier.endpage1040en_US
dc.identifier.issn1470-0328en_US
dc.identifier.pmid12269679en_US
dc.identifier.startpage1036en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17951
dc.identifier.volume109en_US
dc.identifier.wosWOS:000178057800013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBaltacı, Abdülkerim
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBjog-an International Journal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleErythromycin Inhibits Prostaglandin F-2 Alpha-İnduced Contractions of Myometrium Isolated From Non-Pregnant Ratsen_US
dc.typeArticleen_US

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