Evaluation of Segregation Patterns of 21;21 Robertsonian Translocation Along With Sex Chromosomes and Interchromosomal Effects in Sperm Nuclei of Carrier by Fish Technique

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dc.contributor.authorAcar, Hasan
dc.contributor.authorYıldırım, Mahmut Selman
dc.contributor.authorÇora, Tülin
dc.contributor.authorCeylaner, Serdar
dc.date.accessioned2020-03-26T16:39:04Z
dc.date.available2020-03-26T16:39:04Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMeiotic segregation patterns of carriers of Robertsonian translocations (RT) are important for assessing the risk of unbalanced forms. We investigated the ratio of sperm with t(21;21) to sperm with nullisomy for chromosome 21; the segregation of the t(21;21) along with sex chromosomes, and also interchromosomal effects on chromosome 10 by using three color fluorescence in situ hybridization (FISH) with telomere specific (Tel 21q) and centromerespecific alpha satellite probes for chromosomes X, Y, and 10. The percentage of cosegregation of t(21;21) with sex chromosomes (49.50%) and without sex chromosomes (46.98%) was not significant. There are no significant differences between the percentages of cosegregation of t(21;21) with chromosome X (23.36%) and with chromosome Y (26.16%). No evidence of an interchromosomal effect on chromosome 10 was detected, the percentage of chromosome 10 aneuploidy being similar to that in controls. In addition, the frequency of diploid sperm nuclei was not significantly higher in the carrier (0.32%) than in the controls (0.44%) (P > 0.05). The sex ratio was similar within the carrier and the controls and between the carrier and the control. Three color-FISH analysis, using different probe combinations, seems a rapid and accurate too[ for direct analysis of meiotic segregation product.en_US
dc.identifier.citationAcar, H., Yıldırım, M. S., Çora, T., Ceylaner, S., (2002). Evaluation of Segregation Patterns of 21;21 Robertsonian Translocation Along With Sex Chromosomes and Interchromosomal Effects in Sperm Nuclei of Carrier by Fish Technique. Molecular Reproduction and Development, (63), 232-236. Doi: 10.1002/mrd.10166
dc.identifier.doi10.1002/mrd.10166en_US
dc.identifier.endpage236en_US
dc.identifier.issn1040-452Xen_US
dc.identifier.pmid12203833en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://dx.doi.org/10.1002/mrd.10166
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17956
dc.identifier.volume63en_US
dc.identifier.wosWOS:000177706800011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, Hasan
dc.institutionauthorYıldırım, Mahmut Selman
dc.institutionauthorÇora, Tülin
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofMolecular Reproduction and Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectspermen_US
dc.subjectFISHen_US
dc.subjectRobertsonian translocationen_US
dc.subjectcarrieren_US
dc.titleEvaluation of Segregation Patterns of 21;21 Robertsonian Translocation Along With Sex Chromosomes and Interchromosomal Effects in Sperm Nuclei of Carrier by Fish Techniqueen_US
dc.typeArticleen_US

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