The effects of CO2 pneumoperitoneum on the apoptotic index in the peritoneum

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dc.contributor.authorTosun, Murat
dc.contributor.authorSamli, Hale
dc.contributor.authorArikan, Yueksel
dc.contributor.authorSolak, Mustafa
dc.contributor.authorSahin, Ali
dc.contributor.authorSoeylemez, Zafer
dc.contributor.authorKalkan, Serpil
dc.date.accessioned2020-03-26T17:18:29Z
dc.date.available2020-03-26T17:18:29Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDuring laparoscopic surgery, gases such as carbon dioxide (CO2), helium, or normal air are insufflated into the intra-abdominal cavity so the surgeon can obtain a clear surgical field; however, this insufflation technique may cause injury to the intra-abdominal organs. This study was undertaken to evaluate the effects of different pressures of CO2 on the apoptotic index in the peritoneum during laparoscopic surgery. A total of 30 Sprague-Dawley male rats were used in the study. CO2 was insufflated into the intra-abdominal cavity via an angiocatheter cannula by an insufflator at pressures of 10 and 20 mm Hg over 60 min. In the control group, the cannula was inserted into the intra-abdominal cavity, but no gas was insufflated. After 60 min, the rats were killed; peritoneum was harvested from the abdominal wall and was cultured in the cell culture laboratory. Apoptotic and living cells were detected immunohistochemically, and the apoptotic index was calculated and statistically analyzed. The data collected revealed that the apoptotic index increases in proportion to the level of CO2 pressure. CO2 pneumoperitoneum is a very useful technique. Gas pressure must be carefully set during the operation, however, or injured mesothelial cells may cause serious malfunction.en_US
dc.identifier.doi10.1007/BF02849981en_US
dc.identifier.endpage889en_US
dc.identifier.issn0741-238Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid17901037en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage883en_US
dc.identifier.urihttps://dx.doi.org/10.1007/BF02849981
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21673
dc.identifier.volume24en_US
dc.identifier.wosWOS:000250898200020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHEALTH COMMUNICATIONS INCen_US
dc.relation.ispartofADVANCES IN THERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCO2 pneumoperitoneumen_US
dc.subjectapoptosisen_US
dc.subjectapoptotic indexen_US
dc.subjectperitoneumen_US
dc.subjectcell cultureen_US
dc.titleThe effects of CO2 pneumoperitoneum on the apoptotic index in the peritoneumen_US
dc.typeArticleen_US

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