Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels After Cerebral Ischemia

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dc.contributor.authorBarışkaner, Hülagü
dc.contributor.authorÜstün, M. E.
dc.contributor.authorAk, A.
dc.contributor.authorYosunkaya, Alper
dc.contributor.authorUlusoy, H. B.
dc.contributor.authorGürbilek, Mehmet
dc.date.accessioned2020-03-26T16:45:41Z
dc.date.available2020-03-26T16:45:41Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the effects of magnesium sulfate on tissue lactate and malondialdehyde (MIDA) levels after cerebral ischemia in rabbits were studied. The rabbits were divided equally into three groups. Group 1 (n = 8) was the sham-operated control group, in group 2 (n = 8) only cerebral ischemia was induced by clamping bilaterally the common carotid arteries for 60 min, and in group 3 (n = 8) magnesium sulfate was administered at a dose of 100 mg/kg im. within 5 min after opening the clamps. In group 1 EEG recordings were obtained immediately and 60 and 120 min after craniectomy. In groups 2 and 3 EEG recordings were obtained immediately after craniectomy but before clamping and 60 min after clamping. One hour after opening the clamps and taking EEG recordings, brain cortices were resected, and the concentrations of lactate and MIDA were determined using spectrophotometric/enzymatic and thiobarbituric acid methods, respectively. In all groups, there were significant differences between MDA and lactate levels (p < 0.05). There were no significant differences in lactate levels between groups 2 and 3 (p > 0.05), and also the preischemic EEG grades were the same in all groups. Preischemic and postischemic EEG values were significantly different (p < 0.05), and there were also significant differences between postischemic EEG grades in groups 2 and 3 (p < 0.05). There was a correlation between postischemic EEG grades and MIDA and lactate levels. These results demonstrate that cerebral ischemia-reperfusion injury leads to an increase in brain tissue lactate and MIDA levels, that magnesium sulfate suppresses the increase of MDA and lactate concentrations, and that magnesium sulfate, treatment improves the EEG changes. The EEG grades correlated well with MIDA and lactate levels.en_US
dc.description.provenanceMade Available in Dspace on 2020-03-26t16:45:41z (Gmt). No. Of Bitstreams: 0 Previous Issue Date: 2003en
dc.identifier.citationBarışkaner, H., Üstün, M. E., Ak, A., Yosunkaya, A., Ulusoy, H. B., Gürbilek, M., (2003). Effects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels After Cerebral Ischemia. Pharmacology, (68), 162-168. Doi: 10.1159/000070174
dc.identifier.doi10.1159/000070174en_US
dc.identifier.endpage168en_US
dc.identifier.issn0031-7012en_US
dc.identifier.pmid12784088en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000070174
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18453
dc.identifier.volume68en_US
dc.identifier.wosWOS:000183529600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBarışkaner, Hülagü
dc.institutionauthorÜstün, M. E.
dc.institutionauthorAk, A.
dc.institutionauthorYosunkaya, Alper
dc.institutionauthorUlusoy, H. B.
dc.institutionauthorGürbilek, Mehmet
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMagnesium Sulfateen_US
dc.subjectCerebral Ischemiaen_US
dc.subjectLactateen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMalondialdehydeen_US
dc.titleEffects of Magnesium Sulfate on Tissue Lactate and Malondialdehyde Levels After Cerebral Ischemiaen_US
dc.typeArticleen_US

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