Nitric oxide synthase inhibition prevents intestinal damage in gastroschisis: A morphological evaluation in chick embryos

Basit Öğe Kaydı
dc.contributor.authorDilsiz, Alaeddin
dc.contributor.authorGündoğan, Ahmet H.
dc.contributor.authorAktan, Tahsin Murad
dc.contributor.authorDuman, Selçuk
dc.contributor.authorAktuğ, Tanju
dc.date.accessioned2020-03-26T16:27:12Z
dc.date.available2020-03-26T16:27:12Z
dc.date.issued1999
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: Increased small bowel nitric oxide (NO) synthase activity accused for postnatal intestinal dysmotility in gastroschisis. The purpose of this study is to evaluate the effect of prenatal NO synthase inhibition on intestinal damage in gastroschisis. Methods: Sixteen-day-old fertilized chick eggs were divided into 4 groups. In the control group, the allantoic and amniotic membranes were opened to create a common cavity. In the gastroschisis group, a defect in the abdominal wall was made, and intestinal loops were exteriorized. In the gastroschisis pretreated with L-NAME group, gastroschisis was created, and L-NAME was administered into the amnioallantoic cavity for 4 days. In the gastroschisis sham pretreated group, after the same surgical procedure as the previous group, same amount of saline was given beside L-NAME. At the end of 20th day of incubation, intestinal morphological changes were investigated macroscopically and microscopically. Results:Macroscopic changes such as shortening, thickening, and fibrous adhesions were found in the exteriorized bowels of the just gastroschisis group and the gastroschisis pretreated saline group. However, there was only mild thickening in the gastroschisis pretreated with L-NAME group. Microscopically, compared with the gastroschisis group, serosal thickness, muscular thickness, and bowel wall thickness were found to be significantly lower in the gastroschisis pretreated with L-NAME group (128.0 +/- 19.3 pm and 239.5 +/- 3.0 mu m V57.0 +/- 8.2 mu m and 145.0 +/- 9.7 mu m). Conclusion: It is possible to decrease intrauterine intestinal morphological changes in gastroschisis by inhibiting NO synthase. Copyright (C) 1999 by W.B. Saunders Company.en_US
dc.identifier.doi10.1016/S0022-3468(99)90161-6en_US
dc.identifier.endpage1252en_US
dc.identifier.issn0022-3468en_US
dc.identifier.issue8en_US
dc.identifier.pmid10466605en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1248en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0022-3468(99)90161-6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16960
dc.identifier.volume34en_US
dc.identifier.wosWOS:000082043000013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS COen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgastroschisisen_US
dc.subjectintestinal dysfunctionen_US
dc.subjectnitric oxide synthaseen_US
dc.titleNitric oxide synthase inhibition prevents intestinal damage in gastroschisis: A morphological evaluation in chick embryosen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu