Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Volatile anesthetics are known to disturb the spatial memory in aged rodents, but there is insufficient information on their effects on young adult rodents. The aim of this study was to compare the effects of single and repeated exposure to desflurane and sevoflurane on spatial learning and memory functions in young adult mice. Balb/c mice (2months old) were randomly divided into six equal groups (n=8). The groups with single inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 4h, respectively. The groups with repeated inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 2h a day during 5 consecutive days. Spatial learning and memory were tested in the Morris water maze 24h after exposure. In the learning phase, the parameters associated with finding the hidden platform and swimming speed, and in the memory phase, time spent in the target quadrant and the adjacent quadrants, were assessed and compared between the groups. In the 4-day learning process, there was no significant difference between the groups in terms of mean latency to platform, mean distance traveled and average speed (P>0.05). During the memory-test phase, all mice exhibited spatial memory, but there was no significant difference between the groups in terms of time spent in the target quadrant (P>0.05). Sevoflurane and desflurane anesthesia did not impair acquisition learning and retention memory in young adult mice.
Description
Keywords
desflurane, memory, postoperative cognitive dysfunction, sevoflurane, volatile anaesthetics, water maze
Journal or Series
FUNDAMENTAL & CLINICAL PHARMACOLOGY
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
27
Issue
6
