The Comparison of Efficacies of Topical Corticosteroids and Nonsteroidal Anti-inflammatory Drops on Dry Eye Patients: a Clinical and Immunocytochemical Study

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorVarnell, E. D.,
dc.contributor.authorKaufman, H. E.
dc.date.accessioned2020-03-26T16:46:09Z
dc.date.available2020-03-26T16:46:09Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE: To investigate whether conjunctival inflammation represents a primary event in the pathogenesis of keratoconjunctivitis sicca or whether it is a secondary inflammatory reaction caused by enhanced mechanical irritation as a result of surface dryness and whether anti-inflammatory drops (corticosteroids and nonsteroidal anti-inflammatory) have therapeutic effects and are similar. DESIGN: Single-masked, randomized, prospective clinical trial. METHODS: Thirty-two keratoconjuctivitis patients with or without Sjogren syndrome were included in the study. The patients were randomized to three groups. Group I patients received a topical artificial tear substitute (ATS); group 2 received ATS plus nonsteroidal anti-inflammatory drops (NSAID); and group 3 received ATS plus topical corticosteroidal drops. The eye symptom severity scores, Schirmer test values, rose bengal and fluorescein staining scores were evaluated before treatment and 15 and 30 days after start of treatment. Impression cytology specimens were stained using immunohistochemical methods to detect the percentages of human leukocyte antigen II (HLA-DR) positive, Apo 2.7 positive, and periodic acid-Schiff positive cells. Statistical analyses were performed within and between groups. RESULTS: Group 3 patients had significantly lower symptom severity scores, fluorescein and rose bengal staining, and HLA-DR positive cells on days 15 and 30 compared with patients in other groups. They also had a significantly higher number of periodic acid-Schiff positive (goblet) cells in their impression cytology specimens on days 15 and 30 compared with the other patients. On day 30, group 3 patients had significant differences compared with their baseline measurements in terms of above,mentioned parameters. However, we did not detect a significant effect of any treatment schedule on the Shirmer test value and the numbers of Apo 2.7 cells in impression cytology specimens. CONCLUSIONS: Topical corticosteroids had a clearly beneficial effect both on the subjective and objective clinical parameters of moderate-to,severe dry eye patients. These effects were associated with the reduction of inflammation markers of conjunctival epithelial cells. (C) 2003 by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipNEI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [EY02377]en_US
dc.identifier.citationAvunduk, A. M., Avunduk, M. C., Varnell, E. D., Kaufman, H. E., (2003). American Journal of Ophthalmology. American Journal of Ophthalmology, 136(4), 593-602. Doi: 10.1016/S0002-9394(03)00326-X
dc.identifier.doi10.1016/S0002-9394(03)00326-Xen_US
dc.identifier.endpage602en_US
dc.identifier.issn0002-9394en_US
dc.identifier.issue4en_US
dc.identifier.pmid14516798en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0002-9394(03)00326-X
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18579
dc.identifier.volume136en_US
dc.identifier.wosWOS:000185538500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe Comparison of Efficacies of Topical Corticosteroids and Nonsteroidal Anti-inflammatory Drops on Dry Eye Patients: a Clinical and Immunocytochemical Studyen_US
dc.typeArticleen_US

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